CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038010
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Smarca2 
Protein Synonyms/Alias
  
Gene Name
 Smarca2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
438REARMTEKLEKQQKIacetylation[1]
444EKLEKQQKIEQERKRacetylation[1]
528YRKLIDQKKDRRLAYacetylation[1]
611VTHTETGKVLFGPEAacetylation[1]
1004DGSEKDKKGKGGAKTacetylation[1]
1006SEKDKKGKGGAKTLMacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Bromodomain; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1597 AA 
Protein Sequence
MATPTDPAAM PHPGPSPGPG PSPGPILGPS PGPGPSPGSV HSMMGPSPGP PSVSHPMSTM 60
GSADFPQEGL HQLHKPMDGI HDKGIVEDVH CGSMKGTSMR PPHPGMGPPQ SPMDQHSQGY 120
MSPHPSPLGA PEHVSSPISG GGPTPPQMPP SQPGTLIPGD LQAMNQPNRG PSPFSPVQLH 180
QLRAQILAYK MLARGQPLPE TLQLAVQGKR TLPGMQQQQQ QQQQQQQQQQ QQQPQQPQQP 240
QQQTQAQPQQ QQQQQQQPPA LVSYNRPSGP GQELLMTAQN TQQKLSAPAP SGRPSPAPPA 300
ATQPTATAVP GPSVQQPAPG QPSPVLQLQQ KQSRISPIQK PQGLDPVEIL QEREYRLQAR 360
IAHRIQELES LPGSLPPDLR TKATVELKAL RLLNFQRQLR QEVVACMRRD TTLETALNSK 420
AYKRSKRQTL REARMTEKLE KQQKIEQERK RRQKHQEYLN SILQHAKDFK EYHRSVAGKI 480
QKLSKAVATW HANTEREQKK ETERIEKERM RRLMAEDEEG YRKLIDQKKD RRLAYLLQQT 540
DEYVANLTNL VWEHKQAQAA KEKKKRRRRR KKAEENAEGG EPALGPDGEP IDESSQMSDL 600
PVKVTHTETG KVLFGPEAPK ASQLDAWLEM NPGYEVAPRS DSEESESDYE EEDEEEESSR 660
QETEEKILLD PNSEEVSEKD AKQIIETAKQ DVDDEYSMQY SARGSQSYYT VAHAISERVE 720
KQSALLINGT LKHYQLQGLE WMVSLYNNNL NGILADEMGL GKTIQTIALI TYLMEHKRLN 780
GPYLIIVPLS TLSNWTYEFD KWAPSVVKIS YKGTPAMRRS LVPQLRSGKF NVLLTTYEYI 840
IKDKHILAKI RWKYMIVDEG HRMKNHHCKL TQVLNTHYVA PRRILLTGTP LQNKLPELWA 900
LLNFLLPTIF KSCSTFEQWF NAPFAMTGER VDLNEEETIL IIRRLHKVLR PFLLRRLKKE 960
VESQLPEKVE YVIKCDMSAL QKILYRHMQA KGILLTDGSE KDKKGKGGAK TLMNTIMQLR 1020
KICNHPYMFQ HIEESFAEHL GYSNGVINGA ELYRASGKFE LLDRILPKLR ATNHRVLLFC 1080
QMTSLMTIME DYFAFRNFLY LRLDGTTKSE DRAALLKKFN EPGSQYFIFL LSTRAGGLGL 1140
NLQAADTVVI FDSDWNPHQD LQAQDRAHRI GQQNEVRVLR LCTVNSVEEK ILAAAKYKLN 1200
VDQKVIQAGM FDQKSSSHER RAFLQAILEH EEENEEEDEV PDDETLNQMI ARREEEFDLF 1260
MRMDMDRRRE DARNPKRKPR LMEEDELPSW IIKDDAEVER LTCEEEEEKI FGRGSRQRRD 1320
VDYSDALTEK QWLRAIEDGN LEEMEEEVRL KKRKRRRNVD KDPVKEDVEK AKKRRGRPPA 1380
EKLSPNPPKL TKQMNAIIDT VINYKDRCNV EKVPCNSQLE IEGNSSGRQL SEVFIQLPSR 1440
KELPEYYELI RKPVDFKKIK ERIRNHKYRS LGDLEKDVML LCHNAQTFNL EGSQIYEDSI 1500
VLQSVFKSAR QKIAKEEESE EESNEEEEEE DEEESEAEAK SVKVKIKLNK KEEKGRDTGK 1560
GKKRPNRGKA KPVVSDFDSD EEQDENEQSE ASGTDDE 1597 
Gene Ontology
 GO:0045111; C:intermediate filament cytoskeleton; IEA:Compara.
 GO:0071565; C:nBAF complex; IEA:Compara.
 GO:0071564; C:npBAF complex; IEA:Compara.
 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0016514; C:SWI/SNF complex; IEA:Compara.
 GO:0071778; C:WINAC complex; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004386; F:helicase activity; IEA:InterPro.
 GO:0001105; F:RNA polymerase II transcription coactivator activity; IEA:Compara.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara.
 GO:0035887; P:aortic smooth muscle cell differentiation; IEA:Compara.
 GO:0030308; P:negative regulation of cell growth; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara. 
Interpro
 IPR006576; BRK_domain.
 IPR001487; Bromodomain.
 IPR018359; Bromodomain_CS.
 IPR014978; Gln-Leu-Gln_QLQ.
 IPR013999; HAS_subgr.
 IPR014012; Helicase/SANT-assoc_DNA-bd.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR006562; HSA.
 IPR027417; P-loop_NTPase.
 IPR000330; SNF2_N. 
Pfam
 PF07533; BRK
 PF00439; Bromodomain
 PF00271; Helicase_C
 PF07529; HSA
 PF08880; QLQ
 PF00176; SNF2_N 
SMART
 SM00592; BRK
 SM00297; BROMO
 SM00487; DEXDc
 SM00490; HELICc
 SM00573; HSA
 SM00951; QLQ 
PROSITE
 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51204; HSA 
PRINTS
 PR00503; BROMODOMAIN.