UniProt Accession

 PGS1_RAT; P47853 

Genbank Protein ID

 U17834; BC072480 

Genbank Nucleotide ID

 AAA58797.1; AAH72480.1 

Protein Name

 Biglycan 

Protein Synonyms/Alias

 Bone/cartilage proteoglycan I; PG-S1 

Gene Name

 Bgn 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
133	KISKIHEKAFSPLRK	acetylation	[1]
140	KAFSPLRKLQKLYIS	acetylation	[1]
220	YLRISEAKLTGIPKD	acetylation	[1]
255	EDLLRYSKLYRLGLG	acetylation	[1]
289	ELHLDNNKLSRVPAG	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 May be involved in collagen fiber assembly (By similarity). 

Sequence Annotation

 REPEAT 83 103 LRR 1.
 REPEAT 104 127 LRR 2.
 REPEAT 128 151 LRR 3.
 REPEAT 152 172 LRR 4.
 REPEAT 173 196 LRR 5.
 REPEAT 197 221 LRR 6.
 REPEAT 222 242 LRR 7.
 REPEAT 243 266 LRR 8.
 REPEAT 267 290 LRR 9.
 REPEAT 291 313 LRR 10.
 REPEAT 314 343 LRR 11.
 REPEAT 344 369 LRR 12.
 CARBOHYD 42 42 O-linked (Xyl...) (glycosaminoglycan) (By
 CARBOHYD 48 48 O-linked (Xyl...) (glycosaminoglycan) (By
 CARBOHYD 271 271 N-linked (GlcNAc...) (Potential).
 CARBOHYD 312 312 N-linked (GlcNAc...) (Potential).
 DISULFID 64 70 By similarity.
 DISULFID 68 77 By similarity.
 DISULFID 322 355 By similarity.  

Keyword

 Complete proteome; Disulfide bond; Extracellular matrix; Glycoprotein; Leucine-rich repeat; Proteoglycan; Reference proteome; Repeat; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 369 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
 GO:0042383; C:sarcolemma; IEA:Compara.
 GO:0030133; C:transport vesicle; IEA:Compara.
 GO:0050840; F:extracellular matrix binding; IEA:Compara.
 GO:0005539; F:glycosaminoglycan binding; IEA:Compara.
 GO:0001974; P:blood vessel remodeling; IEP:RGD.
 GO:0019800; P:peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; IEA:Compara. 

Interpro

 IPR001611; Leu-rich_rpt.
 IPR000372; LRR-contain_N.
 IPR016352; SLRP_I_decor/aspor/byglycan. 

Pfam

 PF01462; LRRNT 

SMART

 SM00013; LRRNT 

PROSITE

 PS51450; LRR 

PRINTS