CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014922
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 3-ketodihydrosphingosine reductase 
Protein Synonyms/Alias
 KDS reductase; 3-dehydrosphinganine reductase; Follicular variant translocation protein 1 homolog; FVT-1 
Gene Name
 Kdsr 
Gene Synonyms/Alias
 Fvt1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
205EALQMEVKPYNVYVTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). 
Sequence Annotation
 NP_BIND 36 60 NADP (Probable).
 ACT_SITE 186 186 Proton acceptor (By similarity).
 ACT_SITE 190 190 Probable.
 BINDING 173 173 Substrate (By similarity).  
Keyword
 Complete proteome; Endoplasmic reticulum; Lipid metabolism; Membrane; NADP; Oxidoreductase; Proto-oncogene; Reference proteome; Signal; Sphingolipid metabolism; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 332 AA 
Protein Sequence
MLLLAAAGLV AFVLLLYMVS PLISPKPLAL PGAHVVVTGG SSGIGKCIAI ECYKQGAFIT 60
LVARNEDKLL QAKKDIEKHS INDKQVVLCI SVDVSQDYNQ VENVIKQAQE KLGPVDMLVN 120
CAGTSMSGKF EELEVSSFEK LMSINYLGSV YPSRAVITTM KERRVGRIVF VSSQAGQLGL 180
FGFTAYSSSK FAIRGLAEAL QMEVKPYNVY VTVAYPPDTD TPGLAEENKT KPLETRLISE 240
TTAICKPEQV AKQIVKDAIQ GNFNSSIGSD GYMLSSLTCG MAPVTSITEG LQQVVTMGLF 300
RTIALFYLGS FDNIVRRCMV QKAKPEVVDK TA 332 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; ISO:MGI.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0047560; F:3-dehydrosphinganine reductase activity; ISO:MGI.
 GO:0006666; P:3-keto-sphinganine metabolic process; ISO:MGI.
 GO:0030148; P:sphingolipid biosynthetic process; IGI:MGI. 
Interpro
 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 
Pfam
 PF00106; adh_short 
SMART
  
PROSITE
 PS00061; ADH_SHORT 
PRINTS
 PR00081; GDHRDH.
 PR00080; SDRFAMILY.