CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016303
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 F-box only protein 11 
Protein Synonyms/Alias
 Vitiligo-associated protein 1; VIT-1 
Gene Name
 FBXO11 
Gene Synonyms/Alias
 FBX11; VIT1; UG063H01 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
197ANDPILWKRLYMEVFubiquitination[1, 2]
828NNQDAIEKAVSRGQCubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 
Functional Description
 Substrate recognition component of the a (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of TP53. 
Sequence Annotation
 DOMAIN 153 199 F-box.
 REPEAT 395 417 PbH1 1.
 REPEAT 418 440 PbH1 2.
 REPEAT 441 463 PbH1 3.
 REPEAT 464 486 PbH1 4.
 REPEAT 487 509 PbH1 5.
 REPEAT 510 532 PbH1 6.
 REPEAT 533 555 PbH1 7.
 REPEAT 556 578 PbH1 8.
 REPEAT 579 601 PbH1 9.
 REPEAT 602 624 PbH1 10.
 REPEAT 625 647 PbH1 11.
 REPEAT 648 670 PbH1 12.
 REPEAT 671 693 PbH1 13.
 REPEAT 694 716 PbH1 14.
 REPEAT 717 739 PbH1 15.
 REPEAT 740 762 PbH1 16.
 REPEAT 763 785 PbH1 17.
 REPEAT 786 808 PbH1 18.
 REPEAT 809 830 PbH1 19.
 ZN_FING 833 904 UBR-type.  
Keyword
 Alternative splicing; Complete proteome; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Ubl conjugation pathway; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 927 AA 
Protein Sequence
MNSVRAANRR PRRVSRPRPV QQQQQQPPQQ PPPQPPQQQP PQQQPPPPPQ QQQQQQPPPP 60
PPPPPPLPQE RNNVGERDDD VPADMVAEES GPGAQNSPYQ LRRKTLLPKR TACPTKNSME 120
GASTSTTENF GHRAKRARVS GKSQDLSAAP AEQYLQEKLP DEVVLKIFSY LLEQDLCRAA 180
CVCKRFSELA NDPILWKRLY MEVFEYTRPM MHPEPGKFYQ INPEEYEHPN PWKESFQQLY 240
KGAHVKPGFA EHFYSNPARY KGRENMLYYD TIEDALGGVQ EAHFDGLIFV HSGIYTDEWI 300
YIESPITMIG AAPGKVADKV IIENTRDSTF VFMEGSEDAY VGYMTIRFNP DDKSAQHHNA 360
HHCLEITVNC SPIIDHCIIR STCTVGSAVC VSGQGACPTI KHCNISDCEN VGLYITDHAQ 420
GIYEDNEISN NALAGIWVKN HGNPIIRRNH IHHGRDVGVF TFDHGMGYFE SCNIHRNRIA 480
GFEVKAYANP TVVRCEIHHG QTGGIYVHEK GRGQFIENKI YANNFAGVWI TSNSDPTIRG 540
NSIFNGNQGG VYIFGDGRGL IEGNDIYGNA LAGIQIRTNS CPIVRHNKIH DGQHGGIYVH 600
EKGQGVIEEN EVYSNTLAGV WVTTGSTPVL RRNRIHSGKQ VGVYFYDNGH GVLEDNDIYN 660
HMYSGVQIRT GSNPKIRRNK IWGGQNGGIL VYNSGLGCIE DNEIFDNAMA GVWIKTDSNP 720
TLRRNKIHDG RDGGICIFNG GRGLLEENDI FRNAQAGVLI STNSHPILRK NRIFDGFAAG 780
IEITNHATAT LEGNQIFNNR FGGLFLASGV NVTMKDNKIM NNQDAIEKAV SRGQCLYKIS 840
SYTSYPMHDF YRCHTCNTTD RNAICVNCIK KCHQGHDVEF IRHDRFFCDC GAGTLSNPCT 900
LAGEPTHDTD TLYDSAPPIE SNTLQHN 927 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HGNC.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0000151; C:ubiquitin ligase complex; NAS:UniProtKB.
 GO:0016274; F:protein-arginine N-methyltransferase activity; IDA:BHF-UCL.
 GO:0004842; F:ubiquitin-protein ligase activity; NAS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007605; P:sensory perception of sound; IEA:Compara.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; NAS:UniProtKB. 
Interpro
 IPR006633; Carb-bd_sugar_hydrolysis-dom.
 IPR001810; F-box_dom_cyclin-like.
 IPR022441; Para_beta_helix_rpt-2.
 IPR006626; PbH1.
 IPR012334; Pectin_lyas_fold.
 IPR011050; Pectin_lyase_fold/virulence.
 IPR003126; Znf_N-recognin. 
Pfam
 PF02207; zf-UBR 
SMART
 SM00722; CASH
 SM00256; FBOX
 SM00710; PbH1 
PROSITE
 PS50181; FBOX
 PS51157; ZF_UBR 
PRINTS