CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038801
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Ank2 
Protein Synonyms/Alias
  
Gene Name
 Ank2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
46ARAGNLDKVVEYLKGubiquitination[1]
571TPLHVAAKYGSLDVAubiquitination[1]
1180VKKILGNKATFSPIVacetylation[2]
1180VKKILGNKATFSPIVubiquitination[1]
1195TLEPRRRKFHKPITMacetylation[2]
1302AKFVVFAKSHDPIEAacetylation[2]
1383NRLPLFVKVRDTTQEacetylation[2]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3965 AA 
Protein Sequence
MMNEDAAQKS DSGEKFNGSS QRRKRPKKSD SNASFLRAAR AGNLDKVVEY LKGGIDINTC 60
NQNGLNALHL AAKEGHVGLV QELLGRGSSV DSATKKGNTA LHIASLAGQA EVVKVLVKEG 120
ANINAQSQNG FTPLYMAAQE NHIDVVKYLL ENGANQSTAT EDGFTPLAVA LQQGHNQAVA 180
ILLENDTKGK VRLPALHIAA RKDDTKSAAL LLQNDHNADV QSKMMVNRTT ESGFTPLHIA 240
AHYGNVNVAT LLLNRGAAVD FTARNGITPL HVASKRGNTN MVKLLLDRGG QIDAKTRDGL 300
TPLHCAARSG HDQVVELLLE RGAPLLARTK NGLSPLHMAA QGDHVECVKH LLQHKAPVDD 360
VTLDYLTALH VAAHCGHYRV TKLLLDKRAN PNARALNGFT PLHIACKKNR IKVMELLKHA 420
IPTQASSKTD IRPMQQLKNI SHMSSHSLIS QQKKTNQTND CRGETALHMA ARAGQVEVVR 480
CLLRNGALVD ARAREEQTPL HIASRLGKTE IVQLLLQHMA HPDAATTNGY TPLHISAREG 540
QVDVASVLLE AGAAHSLATK KGFTPLHVAA KYGSLDVAKL LLQRRAAADS AGKNGLTPLH 600
VAAHYDNQKV ALLLLEKGAS PHATAKNGYT PLHIAAKKNQ MQIASTLLNY GAETNTVTKQ 660
GVTPLHLASQ EGHTDMVTLL LEKGANIHMS TKSGLTSLHL AAQEDKVNVA DILTKHGADQ 720
DAYTKLGYTP LIVACHYGNV KMVNFLLKQG ANVNAKTKNG YTPLHQAAQQ GHTHIINVLL 780
QHGAKPNATT ANGNTALAIA KRLGYISVVD TLKVVTEEVT TTTTTITEKH KLNVPETMTE 840
VLDVSDEEGE RAPNTSAGQR LKLPDRQWRH TCLLPASLFC DTDILLRKTP EDGGRTINLR 900
SFSSDRSHTL SHASYLRDSA MIDDTVVIPS HQVSALAKEA ERNSYRLSWG TENLDNVALS 960
SSPIHSGFLV SFMVDARGGA MRGCRHNGLR IIIPPRKCTA PTRVTCRLVK RHRLATMPPM 1020
VEGEGLASRL IEVGPSGAQF LGPVIVEIPH FAALRGKERE LVVLRSENGD SWKEHFCEYT 1080
EDELNEILNG MDEVLDSPED LEKKRICRII TRDFPQYFAV VSRIKQDSNL IGPEGGVLSS 1140
TVVSQVQAVF PEGALTKRIR VGLQAQPMHS ELVKKILGNK ATFSPIVTLE PRRRKFHKPI 1200
TMTIPVPKAS SDVMLNGFGG DAPTLRLLCS ITGGTTPAQW EDITGTTPLT FVNECVSFTT 1260
NVSARFWLID CRQIQESVAF ASQVYREIIC VPYMAKFVVF AKSHDPIEAR LRCFCMTDDK 1320
VDKTLEQQEN FSEVARSRDV EVLEGKPIYV DCFGNLVPLT KSGQHHIFSF FAFKENRLPL 1380
FVKVRDTTQE PCGRLSFMKE PKSTRGLVHQ AICNLNITLP IYAKESESDQ EQEEEVILQQ 1440
QHYDETESTE TSVLKSHLVN EVPVLASPDL LSEVSEMKQD LIKMTAILTT DVSDKAGSIK 1500
VKELAKAGEE EPGEPFEIVE RVKEDLEKVN AILRSGTYMR DEGSVRSSQS ERELEEEWVI 1560
VSDEEIEEAK QHAPVEIAEH PCVEVRVDRE TKTKVEKDST GLVNYLTDDL NSYTGTHEKK 1620
PQTAPEKSGE TSQASAIVKS SESNKGKTSP AEEKQSAQKQ VKPSLVIKKP VRRKLKEKQK 1680
QKEESPQGSE EKTELKKGSS EESVDEDRGL APEPLPTAKA TSPLIEETPI GSIKDKVKAL 1740
QKRVEDEQKG RSKLPVRVKG KEDVPKKTTP RTHPVVSPSS KSSPSSKMER HSSLTSSAKT 1800
ERHSPVSPSS KNEKHSPVSP SAKAERHSPV FSGKPEKHSP GSPSTKNERH SPVSSIKTER 1860
HTPVSPSGKT DKRPPVPSSG RTEKHPPVSP GKTEKRSPGA PSIRTPEKQA PGSATGKHEK 1920
HLPVSPGKTE KQPPISPTSK TERIEETMSV RELMKAFQSG QDPSKHKTGL FEHKSAKQKQ 1980
SQDKSKSRVE KEKGHSVTQR ETQRIENQTA KRGQRFQVTG AMESRRFRST TITVGLRTED 2040
PVRERFERTP VIKTPEAVPP VAAAVAAAAA EESHRGAETL QEKTVDEQED MDLQISPDRK 2100
TSTDFSDVIK QELEDNDKYQ QFRLTENTEK AQIHLDQVIT SPFNTTFPLD YMKDEFLPAL 2160
SLQSGALGGS SESLKQEVIA GSPCGSLMEG TPQISSEESY KHEGLAETPE TSPESLSFSP 2220
KKSKEQIGEA KETIKVETPT DIHSEKELPI TNDIADSSEK QGAGVPGDSE HVLKEVTQVP 2280
PKDVCSKQED CPGSHSVSLA NETCQALTEE GSCRDSQLPL VSSACKTQAV SETQESLATS 2340
EVTKAFPPSD ATVKTVEGTE PKPQGVIRSP QGLELPLHNR DSEVLSPMAD ESLAVSHKDS 2400
LEASPVLEDN SSHKTPDSLE PSPLKESPCR DSLESSPVEP KMKAGILPSH FPLPAAIAKT 2460
DLVAEVASMR SRLLRDPDGS AEDDSLEQTS LMESSGKSPL SPDTPSSEEV SYEVTPKPSD 2520
SSTPKPAVIH ECAEEDDSEN GEKKRFTPEE EMFKMVTKIK TFDELEQEAK QKRDYKREPR 2580
QDESSSSSDP DADCSAEVDE QKQMGSTEGE SDVPVLVTSE SRKASSSSES EPELTQLSKG 2640
ADSGLLTEPV IRVQPPSPLP SSIDSNSSPE EAQFQPIVPK QYTFKMNEEV KEDPGNPEED 2700
KDCKSHLAED SQTHSADGAD GSHADLNRET PQLEACDGHG CKAVSPSNSA TPVSLGVQSP 2760
ECHDVDKPLA IDNDSLALQD THGSDLEERE FDPSRVESTQ ASLPSEHSSL SSSSHCAVPE 2820
ENESAKEISS PSSPVKVEVT VTDPVLESMS EDCPTQEAST TTHTERFAMD GPVSDIAETD 2880
ENSHPQITSP YENVASSSFF SGEPSNFQTD TCHPTVVHSP EVYSVIIRSS PEDVIMTSSS 2940
SRTDSGEASN CEGHDLDTEC EQKSALWPMQ SDEPPLSVAP TTPNAPVVTG EQVSKVIITK 3000
TDVDADSWSE IREDDAAFEA RVKEEEQKIF GLMVDRQSQG TTPDTTPART PTEEGTPTSE 3060
QNPFLFQEGK LFEMTRSGAI DMTKRSYADE SLHFFQIGQD SNEETISEDL KEGATGAEPP 3120
QTETTSESLE LSGPKEAMDD EGELVPDDVS EEIEDLPASD ADLDSKVVIS ASTETPTKEA 3180
VSTVAEEPAT MQWSDSLSTV KQTSCPTFPE PVGQLDFSTV TRSVYSDRDD ESPDSSPEEQ 3240
KSVIEIPTAP MENVPSAEIK PQIPIRTLPT SVSAPPSAED ESAFSDDFPS GLDGESEEDG 3300
AKPKSKIPIK APPQRTEWHP SHPDISLQKS GVPQGQDVLS RGPDGRSKSE SDASSLDAKT 3360
KCPVKARSYI ETETESRERA EGFESESEEG ATKPKLFASR LPVKSRSTSS SSRTGTSPTR 3420
ESREHFFDLY RNSIEFFEEI SDEASKLVDR LTQSEREQEP PSDDESSSAL EVSVIENLPP 3480
VDTEHSAPED IFDTRPIWDE SIETMIERIP DENGHDRAED PQDEQERMEE RLAYIADHLG 3540
FSWTELAREL DFTEEQIHQI RIENPNSLQD QSHALLKYWL ERDGKHATDT VLIECLTKIN 3600
RMDIVHLLET NTEPLQERMG RTYAEMEQTI TLDHSEGFSV LPEELCAVKE KKEQEASKES 3660
ESSDHPPMVS EEDISVGYST FQDCIPKTEG DSPAAALSPQ MHQESVQQDF SGKMQDQQEY 3720
YVTTPGAEVE DTQKATVIPD SLCKTPEDIS TPPEEAKPCL QTPVAIEHAS PIVQEPEEAS 3780
EPKEESSPRK TSLVIVESTD DQPQVFEKLD GDAAFQKGDD MPDIPPETVT EEEYVDENGH 3840
TVVKKVTRKI IRRYVSSDGT EKEEITMQGM PQEPVNIEDG DSYSKVIKRV VLKSDTQLSE 3900
VTLSEPSIVS GTSQFQAEPV EGRRVSKVVK TTMVHGERME KSLGDSSLAT DLPSAKEDFE 3960
EVQKE 3965 
Gene Ontology
 GO:0005856; C:cytoskeleton; IDA:RGD.
 GO:0045121; C:membrane raft; IDA:RGD.
 GO:0043005; C:neuron projection; IDA:RGD.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0005200; F:structural constituent of cytoskeleton; IDA:RGD.
 GO:0030913; P:paranodal junction assembly; IEP:RGD.
 GO:0051597; P:response to methylmercury; IEP:RGD.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR011029; DEATH-like_dom.
 IPR000488; Death_domain.
 IPR000906; ZU5. 
Pfam
 PF12796; Ank_2
 PF00531; Death
 PF00791; ZU5 
SMART
 SM00248; ANK
 SM00005; DEATH
 SM00218; ZU5 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50017; DEATH_DOMAIN
 PS51145; ZU5 
PRINTS
 PR01415; ANKYRIN.