UniProt Accession

 PIGS_HUMAN; Q96S52; Q6UVX6 

Genbank Protein ID

 AB057723; AY359112; BC069228 

Genbank Nucleotide ID

 BAB60853.1; AAQ89470.1; AAH69228.1 

Protein Name

 GPI transamidase component PIG-S 

Protein Synonyms/Alias

 Phosphatidylinositol-glycan biosynthesis class S protein 

Gene Name

 PIGS 

Gene Synonyms/Alias

 UNQ1873/PRO4316 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
95	HEREIPLKYKMKIKC	ubiquitination	[1, 2]
458	KISNIVIKDDVASEV	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates. 

Sequence Annotation

 CARBOHYD 267 267 N-linked (GlcNAc...) (Potential).
 CARBOHYD 370 370 N-linked (GlcNAc...) (Potential).  

Keyword

 Alternative splicing; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Glycoprotein; GPI-anchor biosynthesis; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 555 AA 

Protein Sequence

Gene Ontology

 GO:0042765; C:GPI-anchor transamidase complex; TAS:UniProtKB.
 GO:0003923; F:GPI-anchor transamidase activity; IEA:Compara.
 GO:0016255; P:attachment of GPI anchor to protein; TAS:UniProtKB.
 GO:0006501; P:C-terminal protein lipidation; TAS:Reactome. 

Interpro

 IPR019540; PtdIno-glycan_biosynth_class_S. 

Pfam

 PF10510; PIG-S 

SMART

  

PROSITE

  

PRINTS