Tag | Content |
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CPLM ID | CPLM-020455 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dynein heavy chain 6, axonemal |
Protein Synonyms/Alias | Axonemal beta dynein heavy chain 6; Ciliary dynein heavy chain 6 |
Gene Name | DNAH6 |
Gene Synonyms/Alias | DNAHC6; DNHL1; HL2; KIAA1697 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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4148 | SKDYWIAKGSALLCQ | ubiquitination | [1] |
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Reference | [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA. Mol Cell Proteomics. 2012 May;11(5):148-59. [ PMID: 22505724] |
Functional Description | Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). |
Sequence Annotation | NP_BIND 192 199 ATP (Potential). NP_BIND 1472 1479 ATP (Potential). NP_BIND 1753 1760 ATP (Potential). NP_BIND 2096 2103 ATP (Potential). NP_BIND 2447 2454 ATP (Potential). REGION 1 1433 Stem (By similarity). REGION 1434 1655 AAA 1 (By similarity). REGION 1715 1948 AAA 2 (By similarity). REGION 2058 2306 AAA 3 (By similarity). REGION 2408 2659 AAA 4 (By similarity). REGION 2676 2961 Stalk (By similarity). REGION 3042 3272 AAA 5 (By similarity). REGION 3509 3730 AAA 6 (By similarity). |
Keyword | Alternative splicing; ATP-binding; Cell projection; Cilium; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Dynein; Microtubule; Motor protein; Nucleotide-binding; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 4158 AA |
Protein Sequence | MTFRATDSEF DLTNIEEYAE NSALSRLNNI KAKQRVSYVT STENESDTQI LTFRHITKAQ 60 EKTRKRQQPI KLEPLPVLKV YQDHKQPEYI HEQNRFQLMT AGIIKRPVSI AKKSFATSST 120 QFLEHQDAVK KMQIHRPYVE VFSPSPPKLP HTGIGKRGLF GTRSSAYPKY TFHDREEVVK 180 ANIRDPLQII KIIRENEHLG FLYMIPAVPR SSIEYDTYNL KVVSYENINK NDYYTISQRA 240 VTHIYNEDIE FIEIDRWEQE YLYHRELTKI PIFSLFRKWK AFSVWRKNVR SKKITGCQKS 300 LQKNLFIVNP HLRPALLKIN ELCYHLSFMG LCYIEKCHTY TLQEFKAAQV IRLAEVTERL 360 GEFRNEAKYV VRRACRFALR AAGFVPDDCA FGPFEDYHKV QSSGSFINTP HELPTYGDSE 420 KMTYTEQASK RHYCMRLTCF IRLNDYLIEN TMHILTVNAV NSLLNHLTDK LKRTPSADVI 480 QKWITEEKPE VPDKKGTLMV EKQEEDESLI PMFLTELMLT VQSLLFEPSL EDFLDGILGA 540 VNHCQNTVLS VPNLVPDSYF DAFTSPYINN KLEGKTCGTG PSLAAVFEDD KNFHTIISQI 600 KETIQAAFES ARIYAATFEK FQIFFKENES LDLQALKLQE PDINFFSEQL EKYHKQHKDA 660 VALRPTRNVG LLLIDTRLLR EKLIPSPLRC LEVLNFMLPR QSKKKVDAII FEAQDAEYKL 720 EFVPTTTTEY VHSLLFLDEI QERIESLEDE GNIVTQMYKL MEQYQVPTPP EDFAVFATMK 780 PSIVAVRNAI DKSVGDRESS IKQFCVHLGS DLEELNNEVN EVKLQAQDPQ ILDISADQDK 840 IRLILNNLQS VLADLQKRAF QYKSYQKNFK VEVSKFEALE EVSAELKLKQ LLWDSFSEWD 900 KLQQEWLKSK FDCLDPEVLN GQVSKYAKFV TQLEKGLPPN SVVPQLKYKV EKMKEKLPVI 960 IDLRNPTLKA RHWAAIEQTV DATLVDAEIP LTLERLSQLH VFDFGQEIQD ISGQASGEAA 1020 LEAILKKVED SWKTTEFVIL PHRDSKDVFI LGGTDDIQVL LDDSTINVAT LASSRYLGPL 1080 KTRVDEWQKQ LALFNQTLEE WLTCQRNWLY LESIFNAPDI QRQLPAEAKM FLQVDKSWKE 1140 IMRKVNRLPN ALRAATQPGL LETFQNNNAL LDQIQKCLEA YLESKRVIFP RFYFLSNDEL 1200 LEILAQTRNP QAVQPHLRKC FDSISKLEFA LMPPAEGKIP GIDGEPEKVY TNDILAMLSP 1260 EGERVSLGKG LKARGNVEEW LGKVEEAMFT SLRRLCKAAI ADYQGKLRTD WVVAGHPSQV 1320 ILTVSQIMWC RDLTECLETE HSNHIQALKN FEKVNFERLN ALAAIVQGSL PKLHRNILTA 1380 LITIDVHARD IVTELVQSKV ETVESFDWQR QLRYYWDIDL DNCVARMALS QYTYGYEYLG 1440 ACPRLVITPL TDRCYLCLMG ALQLDLGGAP AGPAGTGKTE TTKDLAKALA IQCVVFNCSD 1500 GLDYKMMGRF FSGLAQSGAW CCFDEFNRID IEVLSVIAQQ LITIRNAKAA KLSRFMFEGR 1560 EIKLVMTCAA FITMNPGYAG RTELPDNLKA LFRPFAMMVP NYALIAEVIL YSEGFESSKI 1620 LARKMTQMYK LCSEQLSQQD HYDFGMRAVK SVLVMAGSLK RENPDLNEDV VLIRALQDSN 1680 LPKFLTDDAL LFSGIISDLF PGVQIPEHDY GILQSTIVDV MNRQNLQPEM CMVRKVIQFY 1740 ETMLVRHGVM LVGPTGGGKT TVYRILAETL GNLQKLGIEN SFYQAVKTYV LNPKSITMGE 1800 LYGEVNNLTL EWKDGLMALS VRAAVNDTSE DHKWIISDGP VDALWIENMN TVLDDNKMLC 1860 LANSERIKLT PQIHMLFEVQ DLRVASPATV SRCGMVFVDP EELKWMPYVK TWMKGISKKL 1920 TEETQEYILN LFQRYVDEGL HFINKKCSQA IPQVDISKVT TLCCLLESLI LGKDGVNLAM 1980 EQTKLNTILC QTFVFCYLWS LGGNLTENYY DSFDTFIRTQ FDDNPDARLP NSGDLWSIHM 2040 DFDTKRLDPW ERIIPTFKYN RDVPFFEMLV PTTDTVRYGY LMEKLLAVKH SVLFTGITGV 2100 GKSVIAKGLL NKIQESAGYV PVYLNFSAQT SSARTQEIIE SKLERKRKNI LGAPGNKRIV 2160 IFVDDLNMPR LDRYGSQPPI ELLRQYQDFG GFYDRNKLFW KEIQDVTIIS ACAPPGGGRN 2220 PVTPRFIRHF SMLCLPMPSE HSLKQIFQAI LNGFLSDFPP AVKQTASSIV EASVEIYNKM 2280 SVDLLPTPAK SHYVFNLRDL SKCVQGILQC DPGTIREEIQ IFRLFCHECQ RVFHDRLINN 2340 EDKHYFHVIL TEMANKHFGI AIDLEYFLNK PIIFGDFIKF GADKADRIYD DMPDIEKTAN 2400 VLQDYLDDYN LTNPKEVKLV FFQDAIEHVS RIARMIRQER GNALLVGVGG TGKQSLTRLA 2460 AHICGYKCLQ IELSRGYNYD SFHEDLRKLY KMAGVEDKNM VFLFTDTQIV VEEFLEDINN 2520 ILNSGEVPNL FEKDELEQVL AATRPRAKEV GISEGNRDEV FQYFISKVRQ KLHIVLCMSP 2580 VGEAFRSRCR MFPSLVNCCT IDWFVQWPRE ALLSVSKTFF SQVDAGNEEL KEKLPLMCVN 2640 VHLSVSSMAE RYYNELRRRY YTTPTSYLEL INLYLSMLSE KRKQIISARD RVKNGLTKLL 2700 ETNILVDKMK LDLSALEPVL LAKSEDVEAL MEKLAVDQES ADQVRNTVQE DEATAKVKAE 2760 ETQAIADDAQ RDLDEALPAL DAANKALDSL DKADISEIRV FTKPPDLVMT VMEAISILLN 2820 AKPDWPSAKQ LLGDSNFLKR LLEYDKENIK PQILAKLQKY INNPDFVPEK VEKVSKACKS 2880 MCMWVRAMDL YSRVVKVVEP KRQKLRAAQA ELDITMATLR EKQALLRQVE DQIQALQDEY 2940 DKGVNEKESL AKTMALTKAR LVRAGKLTAA LEDEQVRWEE SIQKFEEEIS NITGNVFIAA 3000 ACVAYYGAFT AQYRQSLIEC WIQDCQSLEI PIDPSFSLIN ILGDPYEIRQ WNTDGLPRDL 3060 ISTENGILVT QGRRWPLMID PQDQANRWIR NKESKSGLKI IKLTDSNFLR ILENSIRLGL 3120 PVLLEELKET LDPALEPILL KQIFISGGRL LIRLGDSDID YDKNFRFYMT TKMPNPHYLP 3180 EVCIKVTIIN FTVTKSGLED QLLSDVVRLE KPRLEEQRIK LIVRINTDKN QLKTIEEKIL 3240 RMLFTSEGNI LDNEELIDTL QDSKITSGAI KTRLEEAEST EQMINVAREK YRPVATQGSV 3300 MYFVIASLSE IDPMYQYSLK YFKQLFNTTI ETSVKTENLQ QRLDVLLEQT LLTAYVNVSR 3360 GLFEQHKLIY SFMLCVEMMR QQGTLSDAEW NFFLRGSAGL EKERPPKPEA PWLPTATWFA 3420 CCDLEESFPV FHGLTQNILS HPISIRLGSF ETYINPQKWE GYSKMKHEDK HMRQEKEAAH 3480 QDPWSAGLSS FHKLILIKCC KEEKVVFALT DFVIENLGKQ FIETPPVDLP TLYQDMSCNT 3540 PLVFILSTGS DPMGAFQRFA RESGYSERVQ SISLGQGQGP IAEKMVKDAM KSGNWVFLQN 3600 CHLAVSWMLA MEELIKTFTD PDSAIKDTFR LFLSSMPSNT FPVTVLQNSV KVTNEPPKGL 3660 RANIRRAFTE MTPSFFEENI LGKKWRQIIF GICFFHAIIQ ERKKFGPLGW NICYEFNDSD 3720 RECALLNLKL YCKEGKIPWD ALIYITGEIT YGGRVTDSWD QRCLRTILKR FFSPETLEED 3780 YKYSESGIYF APMADSLQEF KDYIENLPLI DDPEIFGMHE NANLVFQYKE TSTLINTILE 3840 VQPRSSTGGE GKSNDEIVQE LVASVQTRVP EKLEMEGASE SLFVKDLQGR LNSLTTVLGQ 3900 EVDRFNNLLK LIHTSLETLN KAIAGFVVMS EEMEKVYNSF LNNQVPALWS NTAYPSLKPL 3960 GSWVKDLILR TSFVDLWLKR GQPKSYWISG FFFPQGFLTG TLQNHARKYN LPIDELSFKY 4020 SVIPTYRDQA AVIEAAKTVQ FGQELPMDME LPSPEDGVLV HGMFMDASRW DDKEMVIEDA 4080 LPGQMNPVLP VVHFEPQQNY KPSPTLYHCP LYKTGARAGT LSTTGHSTNF VVTVLLPSKR 4140 SKDYWIAKGS ALLCQLSE 4158 |
Gene Ontology | GO:0005858; C:axonemal dynein complex; IEA:InterPro. GO:0035085; C:cilium axoneme; IEA:UniProtKB-SubCell. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0016887; F:ATPase activity; IEA:InterPro. GO:0003777; F:microtubule motor activity; NAS:UniProtKB. GO:0006200; P:ATP catabolic process; IEA:GOC. GO:0001539; P:ciliary or flagellar motility; IEA:InterPro. GO:0007018; P:microtubule-based movement; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |