CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007186
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Homeotic protein spalt-major 
Protein Synonyms/Alias
  
Gene Name
 salm 
Gene Synonyms/Alias
 sal; CG6464 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
641LPLEVRIKEERVEEQsumoylation[1]
Reference
 [1] Sumoylation modulates the activity of Spalt-like proteins during wing development in Drosophila.
 Sánchez J, Talamillo A, Lopitz-Otsoa F, Pérez C, Hjerpe R, Sutherland JD, Herboso L, Rodríguez MS, Barrio R.
 J Biol Chem. 2010 Aug 13;285(33):25841-9. [PMID: 20562097] 
Functional Description
 Required for the establishment of the posterior-most head and the anterior-most tail segments of the embryo. Probably function as a transcriptional regulator. Could repress the transcription of the tsh gene. 
Sequence Annotation
 ZN_FING 451 473 C2H2-type 1.
 ZN_FING 479 501 C2H2-type 2.
 ZN_FING 824 846 C2H2-type 3.
 ZN_FING 852 874 C2H2-type 4.
 ZN_FING 884 906 C2H2-type 5.
 ZN_FING 1289 1311 C2H2-type 6.
 ZN_FING 1317 1339 C2H2-type 7.
 MOD_RES 739 739 Phosphoserine.
 MOD_RES 744 744 Phosphoserine.
 MOD_RES 1076 1076 Phosphoserine.
 MOD_RES 1079 1079 Phosphoserine.  
Keyword
 Complete proteome; Developmental protein; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1365 AA 
Protein Sequence
MKNHLSNVLC AMRSDFKDNH QETINKMIQF GTVKYGIVKQ LKDRARSADK DIGSDQEENG 60
GCSPLTTATT TASPSRSPEP EEEQPEEQST SEQSIPEQST PDHQLENDIK SEAKSEIEPV 120
EDNNNRVAMT KPSSEEREPN ASGSMPSSPV AEASAEEAAT ERTPEKEKEK DVEVDVEKPD 180
EAPSSAVPST EVTLPGGAGA PVTLEAIQNM QMAIAQFAAK TIANGSNGAD NEAAMKQLAF 240
LQQTLFNLQQ QQLFQIQLIQ QLQSQLALNQ AKQEEDTEED ADQEQDQEQE TDTYEEEERI 300
ADMELRQKAE ARMAEAKARQ HLINAGVPLR ESSGSPAESL KRRREHDHES QPNRRPSLDN 360
THKADTAQDA LAKLKEMENT PLPFGSDLAS SIITNHDDLP EPNSLDLLQK RAQEVLDSAS 420
QGILANSMAD DFAFGEKSGE GKGRNEPFFK HRCRYCGKVF GSDSALQIHI RSHTGERPFK 480
CNVCGSRFTT KGNLKVHFQR HAQKFPHVPM NATPIPEHMD KFHPPLLDQM SPTDSSPNHS 540
PAPPPLGSAP ASFPPAFPGL QNLYRPPMEI LKSLGAAAPH QYFPQELPTD LRKPSPQLDE 600
DEPQVKNEPV EEKDQREEHE QEMAECSEPE PEPLPLEVRI KEERVEEQEQ VKQEDHRIEP 660
RRTPSPSSEH RSPHHHRHSH MGYPPVVQPI QPAALMHPQS SPGSQSHLDH LPTPGQLPPR 720
EDFFAERFPL NFTTAKMLSP EHHSPVRSPA GGALPPGVPP PPHHHPHHMA RSPFFNPIKH 780
EMAALLPRPH SNDNSWENFI EVSNTCETMK LKELMKNKKI SDPNQCVVCD RVLSCKSALQ 840
MHYRTHTGER PFKCRICGRA FTTKGNLKTH MAVHKIRPPM RNFHQCPVCH KKYSNALVLQ 900
QHIRLHTGEP TDLTPEQIQA AEIRDPPPSM MPGHFMNPFA AAAFHFGALP GGPGGPPGPN 960
HGAHNGALGS ESSQGDMDDN MDCGEDYDDD VSSEHLSNSN LEQEGDRSRS GDDFKSLLFE 1020
QKLRIDATGV VNTNPVRPRS SASSHGHSVG STSAPTSPSV HASSQVIKRS SSPARSEASQ 1080
GALDLTPRAA PTSSSSSRSP LPKEKPVSPP SLPRSPSGSS HASANILTSP LPPTVGIDCL 1140
PPGLQHHLQQ QHQHLMQQQA AVAAAAAAQH HHHQQMAALH QHQEQLRREA AEAQQKAAAA 1200
AAAAAAAAAA QRQTPPQARD QRQEGGPGAG PPPNPLMGAR PPFGMFPNLP LFPPATTQNM 1260
CNAMNQIAQS VMPAAPFNPL ALSGVRGSTT CGICYKTFPC HSALEIHYRS HTKERPFKCS 1320
ICDRGFTTKG NLKQHMLTHK IRDMEQETFR NRAVKYMSEW NEDRE 1365 
Gene Ontology
 GO:0005634; C:nucleus; IDA:FlyBase.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0048098; P:antennal joint development; IMP:FlyBase.
 GO:0046845; P:branched duct epithelial cell fate determination, open tracheal system; TAS:FlyBase.
 GO:0007427; P:epithelial cell migration, open tracheal system; TAS:FlyBase.
 GO:0008586; P:imaginal disc-derived wing vein morphogenesis; TAS:FlyBase.
 GO:0030539; P:male genitalia development; IMP:FlyBase.
 GO:0008584; P:male gonad development; IMP:FlyBase.
 GO:0048644; P:muscle organ morphogenesis; IMP:FlyBase.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; NAS:FlyBase.
 GO:0035310; P:notum cell fate specification; IMP:FlyBase.
 GO:0007438; P:oenocyte development; IMP:FlyBase.
 GO:0045466; P:R7 cell differentiation; IMP:FlyBase.
 GO:0045465; P:R8 cell differentiation; IMP:FlyBase.
 GO:0042659; P:regulation of cell fate specification; IMP:FlyBase.
 GO:0007605; P:sensory perception of sound; IMP:FlyBase.
 GO:0007525; P:somatic muscle development; IMP:FlyBase.
 GO:0035277; P:spiracle morphogenesis, open tracheal system; IMP:FlyBase.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS