CPLM 1.0 - Compendium of Protein Lysine Modification| Tag | Content |
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| CPLM ID | CPLM-021521 | UniProt Accession | | Genbank Protein ID | | Genbank Nucleotide ID | | Protein Name | Inositol-pentakisphosphate 2-kinase | Protein Synonyms/Alias | IPK1 homolog; Inositol-1,3,4,5,6-pentakisphosphate 2-kinase; Ins(1,3,4,5,6)P5 2-kinase; InsP5 2-kinase | Gene Name | IPPK | Gene Synonyms/Alias | C9orf12 | Created Date | July 27, 2013 | Organism | Homo sapiens (Human) | NCBI Taxa ID | 9606 | Lysine Modification | Position | Peptide | Type | References |
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| 190 | LDLYSGNKQRMHFAL | ubiquitination | [1] | | 209 | QEAQNNLKIFKNGEL | ubiquitination | [1] | | 357 | EEFPEERKTLQIDGP | ubiquitination | [1, 2] |
| Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] [2] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] | Functional Description | Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. | Sequence Annotation | MOTIF 136 140 EXKPK motif. | Keyword | ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome; Transferase. | Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL | Protein Length | 491 AA | Protein Sequence | MEEGKMDENE WGYHGEGNKS LVVAHAQRCV VLRFLKFPPN RKKTSEEIFQ HLQNIVDFGK 60
NVMKEFLGEN YVHYGEVVQL PLEFVKQLCL KIQSERPESR CDKDLDTLSG YAMCLPNLTR 120
LQTYRFAEHR PILCVEIKPK CGFIPFSSDV THEMKHKVCR YCMHQHLKVA TGKWKQISKY 180
CPLDLYSGNK QRMHFALKSL LQEAQNNLKI FKNGELIYGC KDARSPVADW SELAHHLKPF 240
FFPSNGLASG PHCTRAVIRE LVHVITRVLL SGSDKGRAGT LSPGLGPQGP RVCEASPFSR 300
SLRCQGKNTP ERSGLPKGCL LYKTLQVQML DLLDIEGLYP LYNRVERYLE EFPEERKTLQ 360
IDGPYDEAFY QKLLDLSTED DGTVAFALTK VQQYRVAMTA KDCSIMIALS PCLQDASSDQ 420
RPVVPSSRSR FAFSVSVLDL DLKPYESIPH QYKLDGKIVN YYSKTVRAKD NAVMSTRFKE 480
SEDCTLVLHK V 491 | Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0035299; F:inositol pentakisphosphate 2-kinase activity; IDA:HGNC. GO:0043647; P:inositol phosphate metabolic process; TAS:Reactome. GO:0052746; P:inositol phosphorylation; IDA:BHF-UCL. | Interpro | | Pfam | | SMART | | PROSITE | | PRINTS | |
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