UniProt Accession

 PPIA_BOVIN; P62935; P04374; P10110; Q29580; Q56JX4 

Genbank Protein ID

 AY911355; BC105173 

Genbank Nucleotide ID

 AAW82121.1; AAI05174.1 

Protein Name

 Peptidyl-prolyl cis-trans isomerase A 

Protein Synonyms/Alias

 PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 

Gene Name

 PPIA 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Bos taurus (Bovine) 

NCBI Taxa ID

 9913 

Lysine Modification

Position	Peptide	Type	References
28	SFELFADKVPKTAEN	ubiquitination	[1]
31	LFADKVPKTAENFRA	ubiquitination	[1]
44	RALSTGEKGFGYKGS	ubiquitination	[1]
49	GEKGFGYKGSCFHRI	ubiquitination	[1]
131	GKHVVFGKVKEGMNI	ubiquitination	[1]
133	HVVFGKVKEGMNIVE	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. 

Sequence Annotation

 DOMAIN 7 163 PPIase cyclophilin-type.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylvaline; in Peptidyl-prolyl cis-
 MOD_RES 21 21 Phosphoserine (By similarity).
 MOD_RES 28 28 N6-acetyllysine; alternate (By
 MOD_RES 44 44 N6-acetyllysine (By similarity).
 MOD_RES 76 76 N6-acetyllysine (By similarity).
 MOD_RES 82 82 N6-acetyllysine (By similarity).
 MOD_RES 93 93 Phosphothreonine (By similarity).
 MOD_RES 125 125 N6-acetyllysine (By similarity).
 MOD_RES 131 131 N6-acetyllysine (By similarity).
 CARBOHYD 108 108 N-linked (GlcNAc...) (Potential).
 DISULFID 62 161
 CROSSLNK 28 28 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Complete proteome; Cyclosporin; Cytoplasm; Direct protein sequencing; Disulfide bond; Glycoprotein; Isomerase; Isopeptide bond; Phosphoprotein; Reference proteome; Rotamase; Secreted; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 164 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0042277; F:peptide binding; IEA:UniProtKB-KW.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; ISS:UniProtKB.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0045069; P:regulation of viral genome replication; ISS:UniProtKB. 

Interpro

 IPR002130; Cyclophilin-like_PPIase_dom.
 IPR024936; Cyclophilin-type_PPIase.
 IPR020892; Cyclophilin-type_PPIase_CS. 

Pfam

 PF00160; Pro_isomerase 

SMART

  

PROSITE

 PS00170; CSA_PPIASE_1
 PS50072; CSA_PPIASE_2 

PRINTS

 PR00153; CSAPPISMRASE.