UniProt Accession

 GBRAP_HUMAN; O95166 

Genbank Protein ID

 AF161586; AB030711; AF044671; AF067171; AF183425 

Genbank Nucleotide ID

 AAD47641.1; BAB21549.1; AAD02337.1; AAD32455.1; AAG09694.1 

Protein Name

 Gamma-aminobutyric acid receptor-associated protein 

Protein Synonyms/Alias

 GABA(A) receptor-associated protein; MM46 

Gene Name

 GABARAP 

Gene Synonyms/Alias

 FLC3B; HT004 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
13	KEEHPFEKRRSEGEK	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. 

Sequence Annotation

 REGION 1 22 Interaction with beta-tubulin.
 REGION 36 117 Interaction with GPHN (By similarity).
 REGION 36 68 Interaction with GABRG2 (Potential).
 LIPID 116 116 Phosphatidylethanolamine amidated  

Keyword

 3D-structure; Apoptosis; Autophagy; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Golgi apparatus; Lipoprotein; Membrane; Microtubule; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 117 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0000421; C:autophagic vacuole membrane; IDA:UniProtKB.
 GO:0044297; C:cell body; IEA:Compara.
 GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; IEA:Compara.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005875; C:microtubule associated complex; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; TAS:ProtInc.
 GO:0005790; C:smooth endoplasmic reticulum; IEA:Compara.
 GO:0048487; F:beta-tubulin binding; IDA:UniProtKB.
 GO:0006914; P:autophagy; IEA:UniProtKB-KW.
 GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IDA:UniProtKB.
 GO:0000226; P:microtubule cytoskeleton organization; IEA:Compara.
 GO:0006605; P:protein targeting; TAS:ProtInc.
 GO:0007268; P:synaptic transmission; TAS:ProtInc. 

Interpro

 IPR004241; Atg8_ubiquitin-like. 

Pfam

 PF02991; Atg8 

SMART

  

PROSITE

  

PRINTS