UniProt Accession

 TYRB_ECOLI; P04693; Q2M6Q0 

Genbank Protein ID

 X03628; M12047; U00006; U00096; AP009048; M17809 

Genbank Nucleotide ID

 CAA27278.1; AAA24703.1; AAC43148.1; AAC77024.1; BAE78056.1; AAA24704.1 

Protein Name

 Aromatic-amino-acid aminotransferase 

Protein Synonyms/Alias

 ARAT; AROAT 

Gene Name

 tyrB 

Gene Synonyms/Alias

 b4054; JW4014 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
92	GADHPVLKQQRVATI	acetylation	[1]
116	KVGADFLKRYFPESG	acetylation	[1]
168	NDLLATLKTLPARSI	acetylation	[1]
277	GRVLGQLKATVRRNY	acetylation	[1]
328	AMRQELVKVLSTEMP	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

  

Sequence Annotation

 BINDING 34 34 Substrate; via amide nitrogen (By
 BINDING 66 66 Substrate (By similarity).
 BINDING 131 131 Substrate (By similarity).
 BINDING 184 184 Substrate (By similarity).
 BINDING 281 281 Substrate (By similarity).
 BINDING 375 375 Substrate (By similarity).
 MOD_RES 247 247 N6-(pyridoxal phosphate)lysine.  

Keyword

 3D-structure; Amino-acid biosynthesis; Aminotransferase; Aromatic amino acid biosynthesis; Complete proteome; Cytoplasm; Pyridoxal phosphate; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 397 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:EcoliWiki.
 GO:0008793; F:aromatic-amino-acid:2-oxoglutarate aminotransferase activity; IDA:EcoCyc.
 GO:0050048; F:L-leucine:2-oxoglutarate aminotransferase activity; IMP:EcoCyc.
 GO:0080130; F:L-phenylalanine:2-oxoglutarate aminotransferase activity; IEA:EC.
 GO:0004838; F:L-tyrosine:2-oxoglutarate aminotransferase activity; IDA:EcoCyc.
 GO:0030170; F:pyridoxal phosphate binding; IDA:EcoliWiki.
 GO:0006532; P:aspartate biosynthetic process; IGI:EcoliWiki.
 GO:0033585; P:L-phenylalanine biosynthetic process from chorismate via phenylpyruvate; IDA:EcoCyc.
 GO:0009098; P:leucine biosynthetic process; IMP:EcoCyc.
 GO:0019292; P:tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate; IDA:EcoCyc. 

Interpro

 IPR004839; Aminotransferase_I/II.
 IPR000796; Asp_trans.
 IPR004838; NHTrfase_class1_PyrdxlP-BS.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1. 

Pfam

 PF00155; Aminotran_1_2 

SMART

  

PROSITE

 PS00105; AA_TRANSFER_CLASS_1 

PRINTS

 PR00799; TRANSAMINASE.