UniProt Accession

 MVD1_HUMAN; P53602; Q53Y65 

Genbank Protein ID

 U49260; BT006930; CH471184; BC000011 

Genbank Nucleotide ID

 AAC50440.1; AAP35576.1; EAW66792.1; AAH00011.1 

Protein Name

 Diphosphomevalonate decarboxylase 

Protein Synonyms/Alias

 Mevalonate (diphospho)decarboxylase; MDDase; Mevalonate pyrophosphate decarboxylase 

Gene Name

 MVD 

Gene Synonyms/Alias

 MPD 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
5	***MASEKPLAAVTC	ubiquitination	[1, 2]
58	TTTAVISKDFTEDRI	ubiquitination	[2, 3]
179	MGEQADGKDSIARQV	ubiquitination	[2, 3]
207	LVVSAEKKLTGSTVG	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Performs the first committed step in the biosynthesis of isoprenes. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 96 96 Phosphoserine.  

Keyword

 3D-structure; Acetylation; ATP-binding; Cholesterol biosynthesis; Cholesterol metabolism; Complete proteome; Lipid biosynthesis; Lipid metabolism; Lyase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 400 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004163; F:diphosphomevalonate decarboxylase activity; IDA:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0006695; P:cholesterol biosynthetic process; NAS:UniProtKB.
 GO:0008299; P:isoprenoid biosynthetic process; IDA:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB. 

Interpro

 IPR006204; GHMP_kinase_N_dom.
 IPR005935; Mev_diP_decarb.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr. 

Pfam

 PF00288; GHMP_kinases_N 

SMART

  

PROSITE

  

PRINTS