UniProt Accession

 MED27_DROME; Q9VNG0 

Genbank Protein ID

 AE014297; AY075500 

Genbank Nucleotide ID

 AAF51976.1; AAL68310.1 

Protein Name

 Mediator of RNA polymerase II transcription subunit 27 

Protein Synonyms/Alias

 Mediator complex subunit 27; dCRSP34; dMED27; dTRAP37 

Gene Name

 MED27 

Gene Synonyms/Alias

 Trap37; CG1245 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
12	NSTLTAVKNLRSNVR	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA gene. 

Sequence Annotation

  

Keyword

 Activator; Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 293 AA 

Protein Sequence

Gene Ontology

 GO:0016592; C:mediator complex; IDA:UniProtKB.
 GO:0001104; F:RNA polymerase II transcription cofactor activity; IDA:UniProtKB.
 GO:0046425; P:regulation of JAK-STAT cascade; IMP:FlyBase.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; ISS:FlyBase. 

Interpro

 IPR021627; Mediator_Med27. 

Pfam

 PF11571; Med27 

SMART

  

PROSITE

  

PRINTS