| Tag | Content |
|---|
| CPLM ID | CPLM-015408 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | All-trans retinoic acid-induced differentiation factor |
Protein Synonyms/Alias | Apoptosis-related protein 3; APR-3; p18 |
Gene Name | ATRAID |
Gene Synonyms/Alias | APR3; C2orf28; HSPC013; UNQ214/PRO240 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 108 | SKVAFYCKTTRELML | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. |
Sequence Annotation | DOMAIN 152 193 EGF-like.
CARBOHYD 44 44 N-linked (GlcNAc...) (Potential).
CARBOHYD 79 79 N-linked (GlcNAc...) (Potential).
CARBOHYD 157 157 N-linked (GlcNAc...) (Potential).
CARBOHYD 168 168 N-linked (GlcNAc...) (Potential).
DISULFID 156 171 By similarity.
DISULFID 165 181 By similarity.
DISULFID 183 192 By similarity. |
Keyword | Alternative promoter usage; Alternative splicing; Cell membrane; Complete proteome; Differentiation; Direct protein sequencing; Disulfide bond; EGF-like domain; Glycoprotein; Membrane; Nucleus; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 229 AA |
Protein Sequence | MKTSAELHEQ EKPPSSPRAT GPGRLGHARG RGPDALRGGA AGPGRASSGA PRERKMAPHD 60
PGSLTTLVPW AAALLLALGV ERALALPEIC TQCPGSVQNL SKVAFYCKTT RELMLHARCC 120
LNQKGTILGL DLQNCSLEDP GPNFHQAHTT VIIDLQANPL KGDLANTFRG FTQLQTLILP 180
QHVNCPGGIN AWNTITSYID NQICQGQKNL CNNTGDPEMC PENGSCVPDG PGLLQCVCAD 240
GFHGYKCMRQ GSFSLLMFFG ILGATTLSVS ILLWATQRRK AKTS 284 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005635; C:nuclear envelope; IDA:UniProtKB. GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. GO:2000599; P:negative regulation of cyclin catabolic process; IDA:UniProtKB. GO:0033689; P:negative regulation of osteoblast proliferation; IDA:UniProtKB. GO:0030501; P:positive regulation of bone mineralization; IDA:UniProtKB. GO:0045669; P:positive regulation of osteoblast differentiation; IDA:UniProtKB. GO:0010468; P:regulation of gene expression; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |