UniProt Accession

 INMT_HUMAN; O95050; B8ZZ69; Q3KP49; Q9P1Y2; Q9UBY4; Q9UHQ0 

Genbank Protein ID

 AF128846; AF128847; AF128848; AK313832; AC004976; AC006022; BC033813; BC106902; BC106903; AB041362 

Genbank Nucleotide ID

 AAF18304.1; AAF18305.1; AAF18306.1; AAD04723.1; AAH33813.1; AAI06903.1; AAI06904.1; BAA94451.1 

Protein Name

 Indolethylamine N-methyltransferase 

Protein Synonyms/Alias

 Indolamine N-methyltransferase; Aromatic alkylamine N-methyltransferase; Amine N-methyltransferase; Arylamine N-methyltransferase; Thioether S-methyltransferase; TEMT 

Gene Name

 INMT 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
96	RNREELEKWLKKEPG	acetylation	[1]
112	YDWTPAVKFACELEG	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2- methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds. 

Sequence Annotation

 REGION 85 87 S-adenosyl-L-methionine binding.
 REGION 142 143 S-adenosyl-L-methionine binding.
 BINDING 20 20 S-adenosyl-L-methionine.
 BINDING 25 25 S-adenosyl-L-methionine.
 BINDING 63 63 S-adenosyl-L-methionine; via carbonyl
 BINDING 69 69 S-adenosyl-L-methionine.
 BINDING 90 90 S-adenosyl-L-methionine.
 BINDING 163 163 S-adenosyl-L-methionine; via carbonyl  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Detoxification; Methyltransferase; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 263 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0030748; F:amine N-methyltransferase activity; IDA:UniProtKB.
 GO:0004790; F:thioether S-methyltransferase activity; IEA:EC.
 GO:0009308; P:amine metabolic process; IDA:UniProtKB.
 GO:0009636; P:response to toxic substance; IEA:UniProtKB-KW. 

Interpro

 IPR025817; Amine_MeTrfase.
 IPR025820; NNMT/PNMT/TEMT_CS.
 IPR000940; NNMT_TEMT_trans. 

Pfam

 PF01234; NNMT_PNMT_TEMT 

SMART

  

PROSITE

 PS01100; NNMT_PNMT_TEMT 

PRINTS