CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035928
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ras GTPase-activating-like protein IQGAP2 
Protein Synonyms/Alias
  
Gene Name
 IQGAP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
144QIQDLLGKVDFTEEEubiquitination[1]
563LVKAKELKSERVSSDubiquitination[2, 3]
604TPESCLYKESWLTGKubiquitination[3]
729DHNNEIVKIQSLLRAubiquitination[3]
787LREEVVTKIRANQQLubiquitination[3]
810IKIGLLVKNRITLEDubiquitination[3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 825 AA 
Protein Sequence
MDERRRQNIA YEYLCHLEEA KRWMEVCLVE ELPPTTELEE GLRNGVYLAK LAKFFAPKMV 60
SEKKIYDVEQ TRYKKSGLHF RHTDNTVQWL RAMESIGLPK IFYPETTDVY DRKNIPRMIY 120
CIHALSLYLF KLGIAPQIQD LLGKVDFTEE EISNMRKELE KYGIQMPSFS KIGGILANEL 180
SVDEAALHAA VIAINEAVEK GIAEQTVVTL RNPNAVLTLV DDNLAPEYQK ELWDAKKKKE 240
ENARLKNSCI SEEERDAYEE LLTQAEIQGN INKVNRQAAV DHINAVIPEG DPENTLLALK 300
KPEAQLPAVY PFAAAMYQNE LFNLQKQNTM NYLAHEELLI AVEMLSAVAL LNQALESNDL 360
VSVQNQLRSP AIGLNNLDKA YVERYANTLL SVKLEVLSQG QDNLSWNEIQ NCIDMVNAQI 420
QEENDRVVAV GYINEAIDEG NPLRTLETLL LPTANISDVD PAHAQHYQDV LYHAKSQKLG 480
DSESVSKVLW LDEIQQAVDD ANVDKDRAKQ WVTLVVDVNQ CLEGKKSSDI LSVLKSSTSN 540
ANDIIPECAD KYYDALVKAK ELKSERVSSD GSWLKLNLHK KYDYYYNTDS KESSWVTPES 600
CLYKESWLTG KEIEDIIEEV TVGYIRENIW SASEELLLRF QATSSGPILR EEFEARKSFL 660
HEQEENVVKI QAFWKGYKQR KEYMHRRQTF IDNTDSIVKI QSWFRMATAR KSYLSRLQYF 720
RDHNNEIVKI QSLLRANKAR DDYKTLVGSE NPPLTVIRKF VYLLDQSDLD FQEELEVARL 780
REEVVTKIRA NQQLEKDLNL MDIKIGLLVK NRITLEDVIS HSKKL 825 
Gene Ontology
 GO:0005902; C:microvillus; IEA:Compara. 
Interpro
 IPR001715; CH-domain.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027417; P-loop_NTPase.
 IPR001202; WW_dom. 
Pfam
 PF00307; CH
 PF00612; IQ 
SMART
 SM00033; CH
 SM00015; IQ 
PROSITE
 PS50021; CH
 PS50096; IQ
 PS01159; WW_DOMAIN_1
 PS50020; WW_DOMAIN_2 
PRINTS