CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031402
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sentrin-specific protease 5 
Protein Synonyms/Alias
 cDNA FLJ56806, highly similar to Sentrin-specific protease 5 (EC 3.4.22.-) 
Gene Name
 SENP5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
270AQRSWVQKVTGDHQEubiquitination[1]
513FLDEVMKKYGSLVPLubiquitination[1]
523SLVPLSEKEVLGRLKubiquitination[1, 2]
530KEVLGRLKDVFNEDFubiquitination[2]
700RVRKRIYKELCECRLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protease; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 709 AA 
Protein Sequence
MKKQRKILWR KGIHLAFSEK WNTGFGGFKK FYFHQHLCIL KAKLGRPVTW NRQLRHFQGR 60
KKALQIQKTW IKDEPLCAKT KFNVATQNVS TLSSKVKRKD AKHFISSSKT LLRLQAEKLL 120
SSAKNSDHEY CREKNLLKAV TDFPSNSALG QANGHRPRTD PQPSDFPMKF NGESQSPGES 180
GTIVVTLNNH KRKGFCYGCC QGPEHHRNGG PLIPKKFQLN QHRRIKLSPL MMYEKLSMIR 240
FRYRILRSQH FRTKSKVCKL RKAQRSWVQK VTGDHQETRR ENGEGGSCSP FPSPEPKDPS 300
CRHQPYFPDM DSSAVVKGTN SHVPDCHTKG SSFLGKELSL DEAFPDQQNG SATNAWDQSS 360
CSSPKWECTE LIHDIPLPEH RSNTMFISET EREIMTLGQE NQTSSVSDDR VKLSVSGADT 420
SVSSVDGPVS QKAVQNENSY QMEEDGSLKQ SILSSELLDH PYCKSPLEAP LVCSGLKLEN 480
QVGGGKNSQK ASPVDDEQLS VCLSGFLDEV MKKYGSLVPL SEKEVLGRLK DVFNEDFSNR 540
KPFINREITN YRARHQKCNF RIFYNKHMLD MDDLATLDGQ NWLNDQVINM YGELIMDAVP 600
DKVHFFNSFF HRQLVTKGYN GVKRWTKKNI RKYLLTEARE KNRPEFLQGW QTAVTKCIPQ 660
QKNDSDCGVF VLQYCKCLAL EQPFQFSQED MPRVRKRIYK ELCECRLMD 709 
Gene Ontology
 GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR003653; Peptidase_C48. 
Pfam
 PF02902; Peptidase_C48 
SMART
  
PROSITE
 PS50600; ULP_PROTEASE 
PRINTS