CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029958
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 COP9 signalosome complex subunit 1 
Protein Synonyms/Alias
 MCG2137, isoform CRA_a 
Gene Name
 Gps1 
Gene Synonyms/Alias
 mCG_2137 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
244QTQAILTKLKCAAGLacetylation[1]
244QTQAILTKLKCAAGLubiquitination[2]
246QAILTKLKCAAGLAEubiquitination[2]
333IFKFYESKYASCLKMacetylation[1]
434QRSTTFEKSLLMGKEubiquitination[2]
440EKSLLMGKEFQRRAKubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 490 AA 
Protein Sequence
MPLPVQVFNL QGAVEPMQID VDPQEDPQNA PDVNYVVENP TLDLEQYAAS YSGLMRIERL 60
QFIADRCPPL RVEALKMALS FVQRTFNVDM YEEIHRKLSE ATRELQNAPD AIPESGVEPP 120
PLDTAWVEAT RKKALLKLEK LDTDLKNYKG NSIKESIRRG HDDLGDHYLD CGDLSNALKC 180
YSRARDYCTS AKHVINMCLN VIKVSVYLQN WSHVLSYVSK AESTPEIAEQ RGERDSQTQA 240
ILTKLKCAAG LAELAARKYK QAAKCFLLAS FDHCDFPELL SPSNVAVYGG LCALATFDRQ 300
ELQRNVISSS SFKLFLELEP QVRDIIFKFY ESKYASCLKM LDEMKDNLLL DMYLAPHVRT 360
LYTQIRNRAL IQYFSPYVSA DMHKMAAAFN TTVAALEDEL TQLILEGLIN ARIDSHSKIL 420
YARDVDQRST TFEKSLLMGK EFQRRAKAMI LRAAVLRNQI HVKVKSLGCE GMGGTHTAST 480
EPSLSTAVSS 490 
Gene Ontology
 GO:0008180; C:signalosome; IDA:MGI. 
Interpro
 IPR019585; 26S_proteasome_reg_su-Rpn7.
 IPR000717; PCI_dom.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF01399; PCI
 PF10602; RPN7 
SMART
 SM00088; PINT 
PROSITE
  
PRINTS