UniProt Accession

 K6PP_RAT; P47860; Q5HZX8 

Genbank Protein ID

 BC088847; L25387 

Genbank Nucleotide ID

 AAH88847.1; AAA17757.1 

Protein Name

 6-phosphofructokinase type C 

Protein Synonyms/Alias

 Phosphofructo-1-kinase isozyme C; PFK-C; Phosphofructokinase 1; Phosphohexokinase 

Gene Name

 Pfkp 

Gene Synonyms/Alias

 Pfkc 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
15	TSSTSFPKYLEHLSG	ubiquitination	[1]
139	TGANLFRKEWSGLLE	acetylation	[2]
281	GAIDTQNKPITSEKI	ubiquitination	[1]
381	RRFDEAVKLRGRSFE	acetylation	[2]
395	EGNLNTYKRLAIKEP	ubiquitination	[1]
480	GGSILGTKRTLPGKY	acetylation	[2]
486	TKRTLPGKYLEKIAE	acetylation	[2]
490	LPGKYLEKIAEQMHS	acetylation	[2]
666	KGVFDCRKNVLGHMQ	acetylation	[2]
688	FDRNFGTKISAKAME	acetylation	[2]
688	FDRNFGTKISAKAME	ubiquitination	[1]
692	FGTKISAKAMEWISA	ubiquitination	[1]
730	QKRDLLFKPVAELRK	acetylation	[2]
747	DFEHRIPKQQWWLKL	acetylation	[2]
753	PKQQWWLKLRPIMKI	acetylation	[2]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP (By similarity). 

Sequence Annotation

 NP_BIND 44 48 ATP (By similarity).
 NP_BIND 202 206 ATP (By similarity).
 NP_BIND 219 235 ATP (By similarity).
 ACT_SITE 175 175 Proton acceptor (By similarity).
 METAL 233 233 Magnesium; via carbonyl oxygen (By
 BINDING 210 210 Substrate (By similarity).
 BINDING 301 301 Substrate (By similarity).
 BINDING 307 307 Substrate (By similarity).
 BINDING 310 310 Substrate (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 12 12 Phosphoserine (By similarity).
 MOD_RES 386 386 Phosphoserine (By similarity).
 MOD_RES 395 395 N6-acetyllysine (By similarity).
 MOD_RES 486 486 N6-acetyllysine (By similarity).
 MOD_RES 651 651 Phosphotyrosine (By similarity).
 MOD_RES 688 688 N6-acetyllysine (By similarity).
 CARBOHYD 540 540 O-linked (GlcNAc...) (By similarity).  

Keyword

 Acetylation; Allosteric enzyme; ATP-binding; Complete proteome; Glycolysis; Glycoprotein; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 788 AA 

Protein Sequence

Gene Ontology

 GO:0005945; C:6-phosphofructokinase complex; IEA:InterPro.
 GO:0003872; F:6-phosphofructokinase activity; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IDA:RGD.
 GO:0070095; F:fructose-6-phosphate binding; IDA:RGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0030388; P:fructose 1,6-bisphosphate metabolic process; IDA:RGD.
 GO:0006002; P:fructose 6-phosphate metabolic process; IDA:RGD.
 GO:0006096; P:glycolysis; IDA:RGD.
 GO:0051289; P:protein homotetramerization; IDA:RGD. 

Interpro

 IPR009161; 6-phosphofructokinase_euk.
 IPR022953; Phosphofructokinase.
 IPR015912; Phosphofructokinase_CS.
 IPR000023; Phosphofructokinase_dom. 

Pfam

 PF00365; PFK 

SMART

  

PROSITE

 PS00433; PHOSPHOFRUCTOKINASE 

PRINTS

 PR00476; PHFRCTKINASE.