CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028936
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Exosome complex component RRP4 
Protein Synonyms/Alias
  
Gene Name
 EXOSC2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
165TRSLKYGKVSPSLVKacetylation[1]
261ASLPHQIKDILKPEIubiquitination[2]
265HQIKDILKPEIMEEIubiquitination[2]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 285 AA 
Protein Sequence
MAMEMRLPVA RKPLSERLGR DTKKHLVVPG DTITTDTGFM RGHGTYMGEE KLIASVAGSV 60
ERVNKLICVK ALKTRYIGEV GDIVVGRITE VQQKRWKVET NSRLDSVLLL SSMNLPGGEL 120
RRRSAEDELA MRGFLQEGDL ISAEVQAVFS DGAVSLHTRS LKYGKVSPSL VKRQKTHFHD 180
LPCGASVILG NNGFIWIYPT PEHKEEEAGG FIANLEPVSL ADREVISRLR NCIISLVTQR 240
MMLYDTSILY CYEASLPHQI KDILKPEIME EIVMETRQRL LEQEG 285 
Gene Ontology
 GO:0000178; C:exosome (RNase complex); IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:InterPro. 
Interpro
 IPR025721; Exosome_cplx_N_dom.
 IPR026699; Exosome_RNA_bind1/RRP40/RRP4.
 IPR022967; RNA-binding_domain_S1. 
Pfam
 PF14382; ECR1_N 
SMART
 SM00316; S1 
PROSITE
  
PRINTS