UniProt Accession

 UGDH_MOUSE; O70475 

Genbank Protein ID

 AF061017; BC006749 

Genbank Nucleotide ID

 AAC36096.1; AAH06749.1 

Protein Name

 UDP-glucose 6-dehydrogenase 

Protein Synonyms/Alias

 UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH 

Gene Name

 Ugdh 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
67	VVESCRGKNLFFSTN	ubiquitination	[1]
94	ISVNTPTKTYGMGKG	ubiquitination	[1]
107	KGRAADLKYIEACAR	ubiquitination	[1]
124	VQNSNGYKIVTEKST	ubiquitination	[1]
149	RIFDANTKPNLNLQV	ubiquitination	[1]
173	GTAIKDLKNPDRVLI	acetylation	[2]
190	DETPEGQKAVRALCA	ubiquitination	[1]
205	VYEHWVPKEKILTTN	ubiquitination	[1]
207	EHWVPKEKILTTNTW	ubiquitination	[1]
329	LFNTVTDKKIAILGF	ubiquitination	[1]
355	SSSIYISKYLMDEGA	ubiquitination	[1]
370	HLHIYDPKVPREQIV	ubiquitination	[1]
434	RIHKKMLKPAFIFDG	ubiquitination	[1]
464	FQIETIGKKVSSKRI	ubiquitination	[1]
480	YTPGEIPKFSLQDPP	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. 

Sequence Annotation

 NP_BIND 11 16 NAD (By similarity).
 NP_BIND 89 93 NAD (By similarity).
 NP_BIND 130 131 NAD (By similarity).
 NP_BIND 276 279 NAD (By similarity).
 REGION 161 165 Substrate binding (By similarity).
 REGION 220 227 Substrate binding (By similarity).
 REGION 260 273 Substrate binding (By similarity).
 REGION 338 339 Substrate binding (By similarity).
 ACT_SITE 276 276 Nucleophile (By similarity).
 BINDING 36 36 NAD (By similarity).
 BINDING 41 41 NAD (By similarity).
 BINDING 165 165 NAD (By similarity).
 BINDING 346 346 NAD (By similarity).
 BINDING 442 442 Substrate (By similarity).
 MOD_RES 107 107 N6-acetyllysine (By similarity).
 MOD_RES 473 473 Phosphotyrosine.
 MOD_RES 474 474 Phosphothreonine.  

Keyword

 Acetylation; Allosteric enzyme; Complete proteome; NAD; Oxidoreductase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 493 AA 

Protein Sequence

Gene Ontology

 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:EC.
 GO:0001702; P:gastrulation with mouth forming second; IMP:MGI.
 GO:0006065; P:UDP-glucuronate biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR008927; 6-PGluconate_DH_C-like.
 IPR016040; NAD(P)-bd_dom.
 IPR017476; Nucleotide_sugar_DH.
 IPR014027; UDP-Glc/GDP-Man_DH_C.
 IPR014026; UDP-Glc/GDP-Man_DH_dimer.
 IPR001732; UDP-Glc/GDP-Man_DH_N. 

Pfam

 PF00984; UDPG_MGDP_dh
 PF03720; UDPG_MGDP_dh_C
 PF03721; UDPG_MGDP_dh_N 

SMART

 SM00984; UDPG_MGDP_dh_C 

PROSITE

  

PRINTS