CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012510
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pericentriolar material 1 protein 
Protein Synonyms/Alias
 PCM-1; hPCM-1 
Gene Name
 PCM1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
102PEQAELEKLKQRINFubiquitination[1]
277MEEIENLKKQHDLLKubiquitination[1]
393SERLPDEKVELFSKMubiquitination[1]
399EKVELFSKMRVLQEKubiquitination[1]
412EKKQKMDKLLGELHTubiquitination[1]
489GHLNPSEKLQKLNEVubiquitination[1]
658EDAEFEQKINRLMAAubiquitination[1]
707YPAEEDTKQNSNNTRubiquitination[1]
738REKFYEAKLQQQQREubiquitination[1]
787VGNCPTKKYMPAVTSubiquitination[1]
807QHETSTSKSVFEPEDubiquitination[1]
841EELRQRRKQLEALMAubiquitination[1]
1076QNNVQRLKQMLNELMubiquitination[1]
1181TEYMAFPKPFESSSSubiquitination[1]
1197GAEKPRNKKLPEEEVubiquitination[1]
1221EQEGEVEKPFIKTGFubiquitination[1]
1225EVEKPFIKTGFSVSVubiquitination[1]
1646DNNSITVKQRCKRKIubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Involved in the biogenesis of cilia. 
Sequence Annotation
 REGION 1279 1799 Interaction with HAP1.
 REGION 1913 2024 Interaction with BBS4.
 MOD_RES 65 65 Phosphoserine.
 MOD_RES 68 68 Phosphoserine.
 MOD_RES 69 69 Phosphoserine.
 MOD_RES 93 93 Phosphoserine.
 MOD_RES 110 110 Phosphoserine.
 MOD_RES 399 399 N6-acetyllysine.
 MOD_RES 431 431 Phosphoserine.
 MOD_RES 861 861 Phosphoserine.
 MOD_RES 866 866 Phosphoserine (By similarity).
 MOD_RES 960 960 Phosphoserine.
 MOD_RES 1185 1185 Phosphoserine.
 MOD_RES 1231 1231 Phosphoserine.
 MOD_RES 1257 1257 Phosphoserine.
 MOD_RES 1260 1260 Phosphoserine.
 MOD_RES 1263 1263 Phosphoserine.
 MOD_RES 1290 1290 Phosphoserine (By similarity).
 MOD_RES 1435 1435 Phosphoserine (By similarity).
 MOD_RES 1437 1437 Phosphoserine (By similarity).
 MOD_RES 1656 1656 Phosphoserine (By similarity).
 MOD_RES 1697 1697 Phosphoserine.
 MOD_RES 1730 1730 Phosphoserine.
 MOD_RES 1765 1765 Phosphoserine.
 MOD_RES 1768 1768 Phosphoserine.
 MOD_RES 1776 1776 Phosphoserine.
 MOD_RES 1958 1958 Phosphoserine.
 MOD_RES 1977 1977 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Chromosomal rearrangement; Cilium biogenesis/degradation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2024 AA 
Protein Sequence
MATGGGPFED GMNDQDLPNW SNENVDDRLN NMDWGAQQKK ANRSSEKNKK KFGVESDKRV 60
TNDISPESSP GVGRRRTKTP HTFPHSRYMS QMSVPEQAEL EKLKQRINFS DLDQRSIGSD 120
SQGRATAANN KRQLSENRKP FNFLPMQINT NKSKDASTSP PNRETIGSAQ CKELFASALS 180
NDLLQNCQVS EEDGRGEPAM ESSQIVSRLV QIRDYITKAS SMREDLVEKN ERSANVERLT 240
HLIDHLKEQE KSYMKFLKKI LARDPQQEPM EEIENLKKQH DLLKRMLQQQ EQLRALQGRQ 300
AALLALQHKA EQAIAVMDDS VVAETAGSLS GVSITSELNE ELNDLIQRFH NQLRDSQPPA 360
VPDNRRQAES LSLTREVSQS RKPSASERLP DEKVELFSKM RVLQEKKQKM DKLLGELHTL 420
RDQHLNNSSS SPQRSVDQRS TSAPSASVGL APVVNGESNS LTSSVPYPTA SLVSQNESEN 480
EGHLNPSEKL QKLNEVRKRL NELRELVHYY EQTSDMMTDA VNENRKDEET EESEYDSEHE 540
NSEPVTNIRN PQVASTWNEV NSHSNAQCVS NNRDGRTVNS NCEINNRSAA NIRALNMPPS 600
LDCRYNREGE QEIHVAQGED DEEEEEEAEE EGVSGASLSS HRSSLVDEHP EDAEFEQKIN 660
RLMAAKQKLR QLQDLVAMVQ DDDAAQGVIS ASASNLDDFY PAEEDTKQNS NNTRGNANKT 720
QKDTGVNEKA REKFYEAKLQ QQQRELKQLQ EERKKLIDIQ EKIQALQTAC PDLQLSAASV 780
GNCPTKKYMP AVTSTPTVNQ HETSTSKSVF EPEDSSIVDN ELWSEMRRHE MLREELRQRR 840
KQLEALMAEH QRRQGLAETA SPVAVSLRSD GSENLCTPQQ SRTEKTMATW GGSTQCALDE 900
EGDEDGYLSE GIVRTDEEEE EEQDASSNDN FSVCPSNSVN HNSYNGKETK NRWKNNCPFS 960
ADENYRPLAK TRQQNISMQR QENLRWVSEL SYVEEKEQWQ EQINQLKKQL DFSVSICQTL 1020
MQDQQTLSCL LQTLLTGPYS VMPSNVASPQ VHFIMHQLNQ CYTQLTWQQN NVQRLKQMLN 1080
ELMRQQNQHP EKPGGKERGS SASHPPSPSL FCPFSFPTQP VNLFNIPGFT NFSSFAPGMN 1140
FSPLFPSNFG DFSQNISTPS EQQQPLAQNS SGKTEYMAFP KPFESSSSIG AEKPRNKKLP 1200
EEEVESSRTP WLYEQEGEVE KPFIKTGFSV SVEKSTSSNR KNQLDTNGRR RQFDEESLES 1260
FSSMPDPVDP TTVTKTFKTR KASAQASLAS KDKTPKSKSK KRNSTQLKSR VKNIKTGSDF 1320
SMFEALRDTI YSEVATLISQ NESRPHFLIE LFHELQLLNT DYLRQRALYA LQDIVSRHIS 1380
ESHEKGENVK SVNSGTWIAS NSELTPSESL ATTDDETFEK NFERETHKIS EQNDADNASV 1440
LSVSSNFEPF ATDDLGNTVI HLDQALARMR EYERMKTEAE SNSNMRCTCR IIEDGDGAGA 1500
GTTVNNLEET PVIENRSSQQ PVSEVSTIPC PRIDTQQLDR QIKAIMKEVI PFLKEHMDEV 1560
CSSQLLTSVR RMVLTLTQQN DESKEFVKFF HKQLGSILQD SLAKFAGRKL KDCGEDLLVE 1620
ISEVLFNELA FFKLMQDLDN NSITVKQRCK RKIEATGVIQ SCAKEAKRIL EDHGSPAGEI 1680
DDEDKDKDET ETVKQTQTSE VYDGPKNVRS DISDQEEDEE SEGCPVSINL SKAETQALTN 1740
YGSGEDENED EEMEEFEEGP VDVQTSLQAN TEATEENEHD EQVLQRDFKK TAESKNVPLE 1800
REATSKNDQN NCPVKPCYLN ILEDEQPLNS AAHKESPPTV DSTQQPNPLP LRLPEMEPLV 1860
PRVKEVKSAQ ETPESSLAGS PDTESPVLVN DYEAESGNIS QKSDEEDFVK VEDLPLKLTI 1920
YSEADLRKKM VEEEQKNHLS GEICEMQTEE LAGNSETLKE PETVGAQSI 1969 
Gene Ontology
 GO:0034451; C:centriolar satellite; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0031965; C:nuclear membrane; IDA:HPA.
 GO:0000242; C:pericentriolar material; ISS:BHF-UCL.
 GO:0042802; F:identical protein binding; ISS:BHF-UCL.
 GO:0051297; P:centrosome organization; IMP:BHF-UCL.
 GO:0042384; P:cilium assembly; IMP:UniProtKB.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
 GO:0022027; P:interkinetic nuclear migration; ISS:BHF-UCL.
 GO:0034453; P:microtubule anchoring; ISS:BHF-UCL.
 GO:0034454; P:microtubule anchoring at centrosome; IEA:Compara.
 GO:0050768; P:negative regulation of neurogenesis; ISS:BHF-UCL.
 GO:0097150; P:neuronal stem cell maintenance; IEA:Compara.
 GO:0071539; P:protein localization to centrosome; ISS:BHF-UCL. 
Interpro
 IPR024138; Pericentriolar_Pcm1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS