UniProt Accession

 AOFA_HUMAN; P21397; B4DF46; Q16426 

Genbank Protein ID

 M69226; M68840; X60806; X60807; X60808; X60809; X60810; X60811; X60812; X60813; X60814; X60815; X60816; X60817; X60818; X60819; M68857; M68843; M68844; M68845; M68846; M68847; M68848; M68849; M68850; M68851; M68852; M68853; M68854; M68855; M68856; AK293926; AL109855; BX530072; BX537147; BX537148; BC008064; M89636; S81371; S72704 

Genbank Nucleotide ID

 AAA59549.1; AAA59548.1; AAA59547.1; AAA59547.1; AAA59547.1; AAA59547.1; AAA59547.1; AAA59547.1; AAA59547.1; AAA59547.1; AAA59547.1; AAA59547.1; AAA59547.1; AAA59547.1; AAA59547.1; AAA59547.1; AAA59547.1; BAG57307.1; AAH08064.1; AAB46385.1; AAD14361.1; AAD14113.1 

Protein Name

 Amine oxidase [flavin-containing] A 

Protein Synonyms/Alias

 Monoamine oxidase type A; MAO-A 

Gene Name

 MAOA 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
136	RTIDNMGKEIPTDAP	acetylation	[1]
218	TNGGQERKFVGGSGQ	ubiquitination	[2]
469	GLGKVTEKDIWVQEP	ubiquitination	[3, 4]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. 

Sequence Annotation

 REGION 520 522 Interaction with membrane phospholipid
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 406 406 S-8alpha-FAD cysteine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Catecholamine metabolism; Complete proteome; Direct protein sequencing; FAD; Flavoprotein; Membrane; Mental retardation; Mitochondrion; Mitochondrion outer membrane; Neurotransmitter degradation; Oxidoreductase; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 527 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; TAS:Reactome.
 GO:0008131; F:primary amine oxidase activity; TAS:Reactome.
 GO:0007610; P:behavior; TAS:ProtInc.
 GO:0006576; P:cellular biogenic amine metabolic process; TAS:ProtInc.
 GO:0042420; P:dopamine catabolic process; IEA:Compara.
 GO:0042136; P:neurotransmitter biosynthetic process; TAS:Reactome.
 GO:0042135; P:neurotransmitter catabolic process; IEA:UniProtKB-KW.
 GO:0007269; P:neurotransmitter secretion; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. 

Interpro

 IPR002937; Amino_oxidase.
 IPR001613; Flavin_amine_oxidase. 

Pfam

 PF01593; Amino_oxidase 

SMART

  

PROSITE

  

PRINTS

 PR00757; AMINEOXDASEF.