UniProt Accession

 ST1E3_RAT; P49889; Q9QWS0 

Genbank Protein ID

 M86758; S76489; AJ131835; AJ298109; AJ298110; AJ298111; AJ298112; AJ298113; AJ298114 

Genbank Nucleotide ID

 AAA41128.1; AAB33441.1; CAA10515.2; CAA10515.2; CAA10515.2; CAA10515.2; CAA10515.2; CAA10515.2; CAA10515.2 

Protein Name

 Estrogen sulfotransferase, isoform 3 

Protein Synonyms/Alias

 EST-3; Estrone sulfotransferase; Sulfotransferase, estrogen-preferring 

Gene Name

 Ste 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
112	VKTHLPAKLLPASFW	acetylation	[1]
182	HVKSWWEKSKNSRVL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol (By similarity). 

Sequence Annotation

 NP_BIND 48 53 PAPS (By similarity).
 NP_BIND 227 232 PAPS (By similarity).
 NP_BIND 257 259 PAPS (By similarity).
 REGION 106 108 Substrate binding (By similarity).
 ACT_SITE 108 108 Proton acceptor (By similarity).
 BINDING 130 130 PAPS (By similarity).
 BINDING 138 138 PAPS (By similarity).
 BINDING 193 193 PAPS (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Lipid-binding; Reference proteome; Steroid-binding; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 295 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004304; F:estrone sulfotransferase activity; IDA:RGD.
 GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
 GO:0008210; P:estrogen metabolic process; TAS:RGD. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR000863; Sulfotransferase_dom. 

Pfam

 PF00685; Sulfotransfer_1 

SMART

  

PROSITE

  

PRINTS