| Tag | Content |
|---|
| CPLM ID | CPLM-015289 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ATP-dependent RNA helicase Dhx29 |
Protein Synonyms/Alias | DEAH box protein 29 |
Gene Name | Dhx29 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1231 | VGKIMCTKSVDVTEK | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mammalian mRNAs with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity (By similarity). |
Sequence Annotation | DOMAIN 581 754 Helicase ATP-binding.
DOMAIN 848 1025 Helicase C-terminal.
NP_BIND 594 601 ATP (By similarity).
MOTIF 701 704 DEAH box.
MOD_RES 69 69 Phosphoserine (By similarity).
MOD_RES 190 190 Phosphoserine (By similarity).
MOD_RES 198 198 Phosphoserine (By similarity). |
Keyword | ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Helicase; Hydrolase; Initiation factor; Nucleotide-binding; Phosphoprotein; Protein biosynthesis; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1365 AA |
Protein Sequence | MGGKNKKHKA PGAAAMRAAV SASRARSAEA GAVGEAQSKK PVARPAPAVP TGAREPRVKQ 60
GPKIYSFNSA NDSGGSANLD KSILKVVINN KLEQRIIGVI NEHKKQNSDR GAISGRLSAK 120
KLQDLYMALQ AFSFKTKDIE DAMTNTLLHG GDLHSALDWL CLNLSDDALP EGFSQEFEEQ 180
QPKSRPKFQS VQIQATLSPP QQTKTKRQEE DPKIKPKKEE TTVEVNMKEW ILRYAEQQDE 240
EEKGEGSKGL EEEEKFDPNQ RYLNLAARLL DAKEQAAAFK LEKNKQGQKE AQEKIRKFQR 300
EMETLEDHPI FNPAIKISHQ QNEKKKPAPA TEAESALNLN LFEKSAAATE EEKGKKKEPH 360
DVRNFDYTAR SWTGKSPKQF LIDWVRKNLP KSPNPSFEKV AVGRYWKCRV RVVRSEDDVL 420
VVCPTILTED GMQAQHLGAT LALYRLVKGQ SVHQLLPPTY RDVWLEWSDE EKKREELNKM 480
ETNKPRDLFI AKLLNKLKQQ QQQQQQQRPE SEKGGSEDPE ESWENLVSDE DLAALSLEPT 540
SAEDLAPVRS LFRRLQSTPK YQRLLKERQQ LPVFKHRDSI VETLKRHRVV VVAGETGSGK 600
STQVPHFLLE DLLLDECGAR KCNIVCTQPR RISAVSLATR VCEELGCESG PGGRNSLCGY 660
QIRMESRASE STRLLYCTTG VLLRKLQEDG LLADVSHVIV DEVHERSVQS DFLLVILKEI 720
LQKRSDLHLI LMSATVDSDK FSTYFTHCPI LRISGRSYPV EVFHLEDIVE ETGFVLEKDS 780
EYCQKFLEEE EEITINVTSK AGGVKKYQEY IPVQSGASPE LNPFYQKYSS RTQHAILYMN 840
PHKINLDLIL ELLVYLDKSP QFRNIEGAVL IFLPGLAHIQ QLYDLLSSDR RFYSERYQVI 900
ALHSVLSTQD QAAAFMFPPP GVRKIVLATN IAETGITIPD VVFVIDTGRT KENKYHESSQ 960
MSSLVETFVS KASALQRQGR AGRVRDGFCF RLYTRERFEG FLDYSVPEIL RVPLEELCLH 1020
IMKCDLGSPE DFLSKALDPP QLQVISNAMN LLRKIGACEP NEPKLTPLGQ HLAALPVNVK 1080
IGKMLIFGAI FGCLEPVATL AAVMTEKSPF ITPIGRKDEA DLAKSSLAVA DSDHLTIYNA 1140
YLGWKKAQQE GGFRSEISYC QRNFLNRTSL LTLEDVKQEL MKLVKAAGFS SSPSWEGRKG 1200
PQTLSFQDIA LLKAVLAAGL YDSVGKIMCT KSVDVTEKLA CMVETAQGKA QVHPSSVNRD 1260
LQTYGWLLYQ EKVRYTRVYL RETTLITPFP VLLFGGDIEV QHRERLLSVD GWIYFQAPVK 1320
IAVIFKQLRV LIDSVLRKKL ENPKMSLEND KILQIITELI KTENN 1365 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:MGI. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro. GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |