CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016976
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DENN domain-containing protein 1C 
Protein Synonyms/Alias
 Connecdenn 3; Protein FAM31C 
Gene Name
 DENND1C 
Gene Synonyms/Alias
 FAM31C 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
50EAMQMVPKFCFPFDVubiquitination[1]
170PPTRGNSKPLSCFVAubiquitination[1]
319LLRLRLRKVALAPGEubiquitination[1, 2]
366EEVFLAQKPGAPLQAubiquitination[1]
385AVHLQLFKQFIEARLubiquitination[1]
394FIEARLEKLNKGEGFubiquitination[1]
397ARLEKLNKGEGFSDQubiquitination[1, 2]
430QLWADNLKKGGGALLubiquitination[1]
431LWADNLKKGGGALLHubiquitination[1]
449AKTQPAVKNMYRSAKubiquitination[1]
460RSAKSGLKGVQSLLMubiquitination[1, 2]
469VQSLLMYKDGDSVLQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. 
Sequence Annotation
 DOMAIN 22 89 UDENN.
 DOMAIN 90 293 DENN.
 DOMAIN 324 391 dDENN.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Guanine-nucleotide releasing factor; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 801 AA 
Protein Sequence
MESRAEGGSP AVFDWFFEAA CPASLQEDPP ILRQFPPDFR DQEAMQMVPK FCFPFDVERE 60
PPSPAVQHFT FALTDLAGNR RFGFCRLRAG TQSCLCILSH LPWFEVFYKL LNTVGDLLAQ 120
DQVTEAEELL QNLFQQSLSG PQASVGLELG SGVTVSSGQG IPPPTRGNSK PLSCFVAPDS 180
GRLPSIPENR NLTELVVAVT DENIVGLFAA LLAERRVLLT ASKLSTLTSC VHASCALLYP 240
MRWEHVLIPT LPPHLLDYCC APMPYLIGVH ASLAERVREK ALEDVVVLNV DANTLETTFN 300
DVQALPPDVV SLLRLRLRKV ALAPGEGVSR LFLKAQALLF GGYRDALVCS PGQPVTFSEE 360
VFLAQKPGAP LQAFHRRAVH LQLFKQFIEA RLEKLNKGEG FSDQFEQEIT GCGASSGALR 420
SYQLWADNLK KGGGALLHSV KAKTQPAVKN MYRSAKSGLK GVQSLLMYKD GDSVLQRGGS 480
LRAPALPSRS DRLQQRLPIT QHFGKNRPLR PSRRRQLEEG TSEPPGAGTP PLSPEDEGCP 540
WAEEALDSSF LGSGEELDLL SEILDSLSMG AKSAGSLRPS QSLDCCHRGD LDSCFSLPNI 600
PRWQPDDKKL PEPEPQPLSL PSLQNASSLD ATSSSKDSRS QLIPSESDQE VTSPSQSSTA 660
SADPSIWGDP KPSPLTEPLI LHLTPSHKAA EDSTAQENPT PWLSTAPTEP SPPESPQILA 720
PTKPNFDIAW TSQPLDPSSD PSSLEDPRAR PPKALLAERA HLQPREEPGA LNSPATPTSN 780
CQKSQPSSRP RVADLKKCFE G 801 
Gene Ontology
 GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; IDA:UniProtKB. 
Interpro
 IPR005112; dDENN_dom.
 IPR001194; DENN_dom.
 IPR005113; uDENN_dom. 
Pfam
 PF03455; dDENN
 PF02141; DENN
 PF03456; uDENN 
SMART
 SM00801; dDENN
 SM00799; DENN
 SM00800; uDENN 
PROSITE
 PS50947; DDENN
 PS50211; DENN
 PS50946; UDENN 
PRINTS