UniProt Accession

 AL7A1_HUMAN; P49419; B2R669; B4DIC7; B4DMA0; E7EPT3; O14619; Q6IPU8; Q9BUL4 

Genbank Protein ID

 S74728; AK312459; AK295526; AK297365; AC093535; AC099513; BC002515; BC071712; BC073174; AF002696 

Genbank Nucleotide ID

 AAB31966.1; BAG35366.1; BAG58439.1; BAG59812.1; AAH02515.3; AAH71712.1; AAH73174.1; AAC51935.1 

Protein Name

 Alpha-aminoadipic semialdehyde dehydrogenase 

Protein Synonyms/Alias

 Alpha-AASA dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1; Betaine aldehyde dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase 

Gene Name

 ALDH7A1 

Gene Synonyms/Alias

 ATQ1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
109	WADIPAPKRGEIVRQ	ubiquitination	[1, 2]
439	ILYVFKFKNEEEVFA	acetylation	[3]
452	FAWNNEVKQGLSSSI	ubiquitination	[1, 2]
528	TCTINYSKDLPLAQG	ubiquitination	[1, 2]
537	LPLAQGIKFQ*****	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism. 

Sequence Annotation

 NP_BIND 274 279 NAD (By similarity).
 ACT_SITE 296 296 Proton acceptor (By similarity).
 ACT_SITE 330 330 Nucleophile.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; Epilepsy; Mitochondrion; NAD; Nucleus; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 539 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0004029; F:aldehyde dehydrogenase (NAD) activity; ISS:UniProtKB.
 GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:EC.
 GO:0004043; F:L-aminoadipate-semialdehyde dehydrogenase activity; EXP:Reactome.
 GO:0006081; P:cellular aldehyde metabolic process; ISS:UniProtKB.
 GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.
 GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniPathway.
 GO:0006554; P:lysine catabolic process; TAS:Reactome.
 GO:0007605; P:sensory perception of sound; TAS:ProtInc. 

Interpro

 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom. 

Pfam

 PF00171; Aldedh 

SMART

  

PROSITE

 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 

PRINTS