UniProt Accession

 LYPA1_RAT; P70470 

Genbank Protein ID

 D63885; U97146; BC085750 

Genbank Nucleotide ID

 BAA09935.1; AAC63430.1; AAH85750.1 

Protein Name

 Acyl-protein thioesterase 1 

Protein Synonyms/Alias

 APT-1; Lysophospholipase 1; Lysophospholipase I; LPL-I; LysoPLA I 

Gene Name

 Lypla1 

Gene Synonyms/Alias

 Apt1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
97	KQAAETVKALIDQEV	acetylation	[1]
105	ALIDQEVKNGIPSNR	acetylation	[1]
224	DVKYFIDKLLPPID*	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity (By similarity). 

Sequence Annotation

 ACT_SITE 119 119 Charge relay system (By similarity).
 ACT_SITE 174 174 Charge relay system (By similarity).
 ACT_SITE 208 208 Charge relay system (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Fatty acid metabolism; Hydrolase; Lipid metabolism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 230 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004622; F:lysophospholipase activity; IDA:RGD.
 GO:0008474; F:palmitoyl-(protein) hydrolase activity; ISS:UniProtKB.
 GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW. 

Interpro

 IPR003140; PLipase/COase/thioEstase. 

Pfam

 PF02230; Abhydrolase_2 

SMART

  

PROSITE

  

PRINTS