UniProt Accession

 STRP1_HUMAN; Q5VSL9; Q0V925; Q5VSL8; Q658K2; Q6ZV31; Q8N598; Q96SN2; Q9C0A2 

Genbank Protein ID

 AB051548; AK027649; AK125054; AL834196; AL772411; AL160006; AL772411; AL160006; AL160006; AL772411; AL160006; AL772411; BC032644; BC094786; BC119814; BC121793 

Genbank Nucleotide ID

 BAB21852.2; BAB55265.1; BAC86034.1; CAH56368.1; CAH70967.1; CAH70967.1; CAH70968.1; CAH70968.1; CAI22715.1; CAI22715.1; CAI22716.1; CAI22716.1; AAH32644.1; AAH94786.1; AAI19815.1; AAI21794.1 

Protein Name

 Striatin-interacting protein 1 

Protein Synonyms/Alias

 Protein FAM40A 

Gene Name

 STRIP1 

Gene Synonyms/Alias

 FAM40A; KIAA1761 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
47	AGLLPGGKAREFNRN	ubiquitination	[1]
99	PEFLMNRKCFEEDFR	ubiquitination	[1, 2]
326	PLPEDSIKVIRNMRA	ubiquitination	[1, 2]
420	TDRLTCPKGLPWAPK	ubiquitination	[1]
536	LAAAPTSKAKTDSIN	ubiquitination	[3]
538	AAPTSKAKTDSINIL	ubiquitination	[1]
722	KLLKVQTKYLGRQWR	methylation	[4]
722	KLLKVQTKYLGRQWR	ubiquitination	[3]
742	TMSAIYQKVRHRLND	ubiquitination	[1, 5, 6]
828	LEREVFSKPISWEEL	ubiquitination	[1, 3, 7]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [7] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 59 59 Phosphoserine (By similarity).
 MOD_RES 335 335 Phosphoserine.
 MOD_RES 560 560 Phosphoserine (By similarity).
 MOD_RES 831 831 Phosphoserine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 837 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0030866; P:cortical actin cytoskeleton organization; IMP:UniProtKB.
 GO:0022604; P:regulation of cell morphogenesis; IMP:UniProtKB. 

Interpro

 IPR021819; DUF3402.
 IPR012486; N1221. 

Pfam

 PF11882; DUF3402
 PF07923; N1221 

SMART

  

PROSITE

  

PRINTS