UniProt Accession

 MBIP1_HUMAN; Q9NS73; Q86TZ2; Q96AS5; Q9BS93; Q9NZE1 

Genbank Protein ID

 AB038523; AF208857; BX248287; AL137226; BC005197; BC016821 

Genbank Nucleotide ID

 BAA94083.1; AAF64271.1; CAD62615.1; AAH05197.1; AAH16821.1 

Protein Name

 MAP3K12-binding inhibitory protein 1 

Protein Synonyms/Alias

 MAPK upstream kinase-binding inhibitory protein; MUK-binding inhibitory protein 

Gene Name

 MBIP 

Gene Synonyms/Alias

 BM-015 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
94	AKLQSPIKEENTTAV	ubiquitination	[1]
118	NKNEVNDKFSIGDLQ	ubiquitination	[1]
140	SDLRDVKKTQIHFDP	ubiquitination	[2]
153	DPEVVQIKAGKAEID	ubiquitination	[1, 2]
170	ISAFIERKQAEINEN	ubiquitination	[2]
235	GIPGSGHKPNSMLRD	ubiquitination	[2]
301	QSVSFSGKRRKVQPP	acetylation	[3]
325	DEKISALKQALLRKS	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. 

Sequence Annotation

 REGION 172 344 Interaction with MAP3K12.
 REGION 271 285 Leucine-zipper 1 (Potential).
 REGION 314 329 Leucine-zipper 2 (Potential).
 MOD_RES 91 91 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 344 AA 

Protein Sequence

Gene Ontology

 GO:0005671; C:Ada2/Gcn5/Ada3 transcription activator complex; IDA:BHF-UCL.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0004860; F:protein kinase inhibitor activity; TAS:ProtInc.
 GO:0043966; P:histone H3 acetylation; IDA:BHF-UCL.
 GO:0000173; P:inactivation of MAPK activity involved in osmosensory signaling pathway; TAS:ProtInc. 

Interpro

 IPR026062; MBIP. 

Pfam

  

SMART

  

PROSITE

  

PRINTS