CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030654
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Drebrin-like protein 
Protein Synonyms/Alias
 cDNA FLJ59450, highly similar to Drebrin-like protein 
Gene Name
 DBNL 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
23YVRVVTEKSPTDWALacetylation[1]
23YVRVVTEKSPTDWALubiquitination[2, 3]
106EPECIMEKVAKASGAacetylation[1, 4]
109CIMEKVAKASGANYSubiquitination[3]
119GANYSFHKESGRFQDubiquitination[3, 4]
139PVGSVYQKTNAVSEIubiquitination[2, 3, 5, 6]
147TNAVSEIKRVGKDSFubiquitination[4]
151SEIKRVGKDSFWAKAubiquitination[3]
256ISSPQPGKLRSPFLQacetylation[1]
256ISSPQPGKLRSPFLQubiquitination[3, 6]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 406 AA 
Protein Sequence
MAANLSRNGP ALQEAYVRVV TEKSPTDWAL FTYEGNSNDI RVAGTGEGGL EEMVEELNSG 60
KVMYAFCRVK DPNSGLPKFV LINWGAHVTI NARAEEDVEP ECIMEKVAKA SGANYSFHKE 120
SGRFQDVGPQ APVGSVYQKT NAVSEIKRVG KDSFWAKAEK EEENRRLEEK RRAEEAQRQL 180
EQERRERELR EAARREQRYQ EQGGEASPQS RTWEQQQEVV SRNRNEQESA VHPREIFKQK 240
ERAMSTTSIS SPQPGKLRSP FLQKQLTQPE THFGREPAAA ISRPRADLPA EEPAPSTPPC 300
LVQAEEEAVY EEPPEQETFY EQPPLVQQQG AGSEHIDHHI QGQGLSGQGL CARALYDYQA 360
ADDTEISFDP ENLITGIEVI DEGWWRGYGP DGHFGMFPAN YVELIE 406 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro. 
Interpro
 IPR002108; Actin-bd_cofilin/tropomyosin.
 IPR001452; SH3_domain. 
Pfam
 PF00241; Cofilin_ADF
 PF00018; SH3_1 
SMART
 SM00102; ADF
 SM00326; SH3 
PROSITE
 PS51263; ADF_H
 PS50002; SH3 
PRINTS