CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039305
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 DNA ligase 
Protein Synonyms/Alias
  
Gene Name
 Lig1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
139LEEHNEDKDKAAKKRacetylation[1]
221KPPARGAKPLSSFFTacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 912 AA 
Protein Sequence
QHSLKSFFQP TTTEGKAKKP EKEIPSSIRE KEPPPKVALK ERNRAVPESD SPVKRPGRKV 60
AQVLSSEGED EDEAPGTPQV QKPVSDSKQS SPPSPDSCPE NSSPSMDISP SGFPKRRTAR 120
KQLPKRTIQD TLEEHNEDKD KAAKKRKKED TQTPTESLTE AEEVKQKEEQ VEDQPTVPPE 180
PTESPESVTL TKTENIPMCK AGVKQKPQEE EQSKPPARGA KPLSSFFTPR KPAVKTEVKQ 240
EESDTPRKEE TKGAPDPTNY NPSKSNYHPI EDACWKHGQK VPFLAVARTF EKIEEVSARL 300
KMVETLSNLL RSVVALSPTD LLPVLYLSLN RLGPPQQGLE LGVGDGVLLK AVAQATGRQL 360
ESIRAEVAEK GDVGLVAENS RSTQRLMLPP PPLTVSGVFT KFCDIARLTG SASMAKKMDI 420
IKGLFVACRY SEARFIARSL SGRLRLGLAE QSVLAALAQA VSLTPPGQEF PTAVVDAGKG 480
KTAEARKMWL EEQGMILKQT FCEVPDLDRI IPVLLEHGLE SLPEHCKLSP GVPLKPMLAH 540
PTRGVREVLK RFEEVDFTCE YKYDGQRAQI HVLEGGEVKI FSRNQEDNSG KYPDIISRIP 600
KIKHPSVTSF ILDTEAVAWD REKKQIQPFQ VLTTRKRKEV DASEIQVQVC LYAFDLIYLN 660
GESLARQPLS RRRQLLRENF VETEGEFVFA TSLDTKDIEQ IAEFLEQSVK DSCEGLMVKT 720
LDVDATYEIA KRSHNWLKLK KDYLEGVGDT LDLVVIGAYL GRGKRAGRYG GFLLAAYDEE 780
SEELQAICKL GTGFSDEELE EHHQSMQALL LPTPRPYVRI DGAVAPDHWL DPSVVWEVKC 840
ADLSLSPIYP AARGLVDKEK GISLRFPRFI RVREDKQPEQ ATTSDQVASL YRKQSQIQNQ 900
QSSDLDSDVE DY 912 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003910; F:DNA ligase (ATP) activity; IEA:EC.
 GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
 GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW. 
Interpro
 IPR000977; DNA_ligase_ATP-dep.
 IPR012309; DNA_ligase_ATP-dep_C.
 IPR012310; DNA_ligase_ATP-dep_cent.
 IPR016059; DNA_ligase_ATP-dep_CS.
 IPR012308; DNA_ligase_ATP-dep_N.
 IPR012340; NA-bd_OB-fold. 
Pfam
 PF04679; DNA_ligase_A_C
 PF01068; DNA_ligase_A_M
 PF04675; DNA_ligase_A_N 
SMART
  
PROSITE
 PS00697; DNA_LIGASE_A1
 PS00333; DNA_LIGASE_A2
 PS50160; DNA_LIGASE_A3 
PRINTS