| Tag | Content |
|---|
| CPLM ID | CPLM-013338 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CCR4-NOT transcription complex subunit 10 |
Protein Synonyms/Alias | |
Gene Name | CNOT10 |
Gene Synonyms/Alias | QtsA-19593 |
Created Date | July 27, 2013 |
Organism | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
NCBI Taxa ID | 9541 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 74 | TAVAEFFKSNQTTTD | ubiquitination | [1] | | 664 | SEYDKARKCLHQAAS | ubiquitination | [1] | | 713 | NQLLPAVKTHSEVRK | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4- NOT complex (By similarity). |
Sequence Annotation | MOD_RES 2 2 N-acetylalanine (By similarity). |
Keyword | Acetylation; Coiled coil; Cytoplasm; Nucleus; RNA-mediated gene silencing; Transcription; Transcription regulation; Translation regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 744 AA |
Protein Sequence | MAADKPADQG AEKHEGTGQS SGITDQEKEL STNAFQAFTS GNYDACLQHL ACLQDINKDD 60
YKIILNTAVA EFFKSNQTTT DNLRQTLNQL KNQVHSAVEE MDGLDDVENS MLYYNQAVIL 120
YHLRQYTEAI SVGEKLYQFI EPFEEKFAQA VCFLLVDLYI LTYQAEKALH LLAVLEKMIS 180
QGNNNKNGKN ETGNNNNKDG SNHKAESGAL IEAAKSKIHQ YIVRAYIQMK SLKACKREIK 240
SVMNTAGNSA PSLFLKSNFE YLRGNYRKAV KLLNSSNIAE HPGFMKTGEC LRCMFWNNLG 300
CIHFAMSKHN LGIFYFKKAL QENDNVCAQL SAGSTDPGKK FSGRPMCTLL TNKRYELLYN 360
CGIQLLHIGR PLAAFECLIE AVQVYHANPR LWLRLAECCI AANKGTSEQE TKGLPSKKGI 420
VQSIVGQGYH RKIVLASQSI QNTVYNDGQS SAIPVASMEF AAICLRNALL LLPEEQQDPK 480
QENGAKNSNQ LGGNTESSES SETCSSKSHD GDKFIPAPPS SPLRKQELEN LKCSILACSA 540
YVALALGDNL MALNHADKLL QQPKLSGSLK FLGHLYAAEA LISLDRISDA ITHLNPENVT 600
DVSLGISSNE QDQGSDKGEN EAMESSGKRA PQCYPSSVNS ARTVMLFNLG SAYCLRSEYD 660
KARKCLHQAA SMIHPKEVPP EAILLAVYLE LQNGNTQLAL QIIKRNQLLP AVKTHSEVRK 720
KPVFQPVHPI QPIQMPAFTT VQRK 744 |
Gene Ontology | GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB. GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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PRINTS | |