UniProt Accession

 PHLA2_HUMAN; Q53GA4; O00496 

Genbank Protein ID

 AF019953; AF001294; AF035444; CR407664; AK223027; BC005034 

Genbank Nucleotide ID

 AAC51912.1; AAB86680.1; AAC17458.1; CAG28592.1; BAD96747.1; AAH05034.1 

Protein Name

 Pleckstrin homology-like domain family A member 2 

Protein Synonyms/Alias

 Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein; Imprinted in placenta and liver protein; Tumor-suppressing STF cDNA 3 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein; p17-Beckwith-Wiedemann region 1 C; p17-BWR1C 

Gene Name

 PHLDA2 

Gene Synonyms/Alias

 BWR1C; HLDA2; IPL; TSSC3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
2	******MKSPDEVLR	ubiquitination	[1]
15	LREGELEKRSDSLFQ	ubiquitination	[1, 2]
25	DSLFQLWKKKRGVLT	ubiquitination	[1, 2, 3]
57	LRFHSILKVDCVERT	ubiquitination	[3]
66	DCVERTGKYVYFTIV	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity). 

Sequence Annotation

 DOMAIN 7 99 PH.
 MOD_RES 3 3 Phosphoserine.
 MOD_RES 42 42 Phosphoserine.
 MOD_RES 141 141 Phosphoserine.
 MOD_RES 144 144 Phosphoserine.
 MOD_RES 151 151 Phosphothreonine.  

Keyword

 Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 152 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0006915; P:apoptotic process; TAS:ProtInc.
 GO:0009887; P:organ morphogenesis; IEA:Compara. 

Interpro

 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 

Pfam

  

SMART

 SM00233; PH 

PROSITE

 PS50003; PH_DOMAIN 

PRINTS