UniProt Accession

 APC10_MOUSE; Q8K2H6; Q9CW24 

Genbank Protein ID

 AK005303; AK041373; BC031460 

Genbank Nucleotide ID

 BAB23942.1; BAC30921.1; AAH31460.1 

Protein Name

 Anaphase-promoting complex subunit 10 

Protein Synonyms/Alias

 APC10; Cyclosome subunit 10 

Gene Name

 Anapc10 

Gene Synonyms/Alias

 Apc10 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
169	VEESSIGKFPRCTTI	acetylation	[1, 2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). 

Sequence Annotation

 DOMAIN 1 185 DOC.  

Keyword

 Cell cycle; Cell division; Complete proteome; Mitosis; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 185 AA 

Protein Sequence

Gene Ontology

 GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.
 GO:0030071; P:regulation of mitotic metaphase/anaphase transition; IEA:InterPro. 

Interpro

 IPR016901; APC_su10.
 IPR004939; APC_su10/DOC_dom.
 IPR008979; Galactose-bd-like. 

Pfam

 PF03256; APC10 

SMART

  

PROSITE

 PS51284; DOC 

PRINTS