CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009783
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribose-phosphate pyrophosphokinase 
Protein Synonyms/Alias
 RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase 
Gene Name
 prs 
Gene Synonyms/Alias
 prsA; Rv1017c; MT1045; MTCY10G2.32 
Created Date
 July 27, 2013 
Organism
 Mycobacterium tuberculosis 
NCBI Taxa ID
 1773 
Lysine Modification
Position
Peptide
Type
References
29ELAEQVAKELDVHVTpupylation[1]
Reference
 [1] Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] .
 Festa RA, McAllister F, Pearce MJ, Mintseris J, Burns KE, Gygi SP, Darwin KH.
 PLoS One. 2010 Jan 6;5(1):e8589. [PMID: 20066036] 
Functional Description
  
Sequence Annotation
 REGION 223 236 Binding of phosphoribosylpyrophosphate
 METAL 136 136 Magnesium (Potential).
 METAL 138 138 Magnesium (Potential).
 METAL 147 147 Magnesium (Potential).
 METAL 151 151 Magnesium (Potential).
 CROSSLNK 29 29 Isoglutamyl lysine isopeptide (Lys-Gln)  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Isopeptide bond; Kinase; Magnesium; Metal-binding; Nucleotide biosynthesis; Nucleotide-binding; Reference proteome; Transferase; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 326 AA 
Protein Sequence
MSHDWTDNRK NLMLFAGRAH PELAEQVAKE LDVHVTSQDA REFANGEIFV RFHESVRGCD 60
AFVLQSCPAP VNRWLMEQLI MIDALKRGSA KRITAVMPFY PYARQDKKHR GREPISARLI 120
ADLLKTAGAD RIVTVDLHTD QIQGFFDGPV DHMRGQNLLT GYIRDNYPDG NMVVVSPDSG 180
RVRIAEKWAD ALGGVPLAFI HKTRDPRVPN QVVSNRVVGD VAGRTCVLID DMIDTGGTIA 240
GAVALLHNDG AGDVIIAATH GVLSDPAAQR LASCGAREVI VTNTLPIGED KRFPQLTVLS 300
IAPLLASTIR AVFENGSVTG LFDGDA 326 
Gene Ontology
 GO:0005618; C:cell wall; IDA:MTBBASE.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:MTBBASE.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IDA:MTBBASE.
 GO:0030145; F:manganese ion binding; IDA:MTBBASE.
 GO:0004749; F:ribose phosphate diphosphokinase activity; IDA:MTBBASE.
 GO:0006015; P:5-phosphoribose 1-diphosphate biosynthetic process; IDA:MTBBASE.
 GO:0006200; P:ATP catabolic process; IDA:MTBBASE.
 GO:0040007; P:growth; IMP:MTBBASE.
 GO:0009165; P:nucleotide biosynthetic process; IEA:UniProtKB-KW.
 GO:0051260; P:protein homooligomerization; IPI:MTBBASE.
 GO:0009156; P:ribonucleoside monophosphate biosynthetic process; IEA:HAMAP. 
Interpro
 IPR000842; PRib_PP_synth_CS.
 IPR000836; PRibTrfase_dom.
 IPR005946; Rib-P_diPkinase. 
Pfam
 PF00156; Pribosyltran 
SMART
  
PROSITE
 PS00114; PRPP_SYNTHASE 
PRINTS