| Tag | Content |
|---|
| CPLM ID | CPLM-006709 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Amiloride-sensitive sodium channel subunit alpha |
Protein Synonyms/Alias | Alpha-NaCH; Epithelial Na(+) channel subunit alpha; Alpha-ENaC; ENaCA; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA |
Gene Name | SCNN1A |
Gene Synonyms/Alias | SCNN1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 22 | QSTPGLMKGNKREEQ | ubiquitination | [1] | | 220 | NNPQVDWKDWKIGFQ | ubiquitination | [1] | | 233 | FQLCNQNKSDCFYQT | ubiquitination | [1] | | 529 | AKVNIFFKELNYKTN | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. |
Sequence Annotation | CARBOHYD 232 232 N-linked (GlcNAc...) (Potential).
CARBOHYD 293 293 N-linked (GlcNAc...) (Potential).
CARBOHYD 312 312 N-linked (GlcNAc...) (Potential).
CARBOHYD 397 397 N-linked (GlcNAc...) (Potential).
CARBOHYD 511 511 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Disease mutation; Glycoprotein; Ion channel; Ion transport; Membrane; Polymorphism; Reference proteome; Sensory transduction; Sodium; Sodium channel; Sodium transport; Taste; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 669 AA |
Protein Sequence | MEGNKLEEQD SSPPQSTPGL MKGNKREEQG LGPEPAAPQQ PTAEEEALIE FHRSYRELFE 60
FFCNNTTIHG AIRLVCSQHN RMKTAFWAVL WLCTFGMMYW QFGLLFGEYF SYPVSLNINL 120
NSDKLVFPAV TICTLNPYRY PEIKEELEEL DRITEQTLFD LYKYSSFTTL VAGSRSRRDL 180
RGTLPHPLQR LRVPPPPHGA RRARSVASSL RDNNPQVDWK DWKIGFQLCN QNKSDCFYQT 240
YSSGVDAVRE WYRFHYINIL SRLPETLPSL EEDTLGNFIF ACRFNQVSCN QANYSHFHHP 300
MYGNCYTFND KNNSNLWMSS MPGINNGLSL MLRAEQNDFI PLLSTVTGAR VMVHGQDEPA 360
FMDDGGFNLR PGVETSISMR KETLDRLGGD YGDCTKNGSD VPVENLYPSK YTQQVCIHSC 420
FQESMIKECG CAYIFYPRPQ NVEYCDYRKH SSWGYCYYKL QVDFSSDHLG CFTKCRKPCS 480
VTSYQLSAGY SRWPSVTSQE WVFQMLSRQN NYTVNNKRNG VAKVNIFFKE LNYKTNSESP 540
SVTMVTLLSN LGSQWSLWFG SSVLSVVEMA ELVFDLLVIM FLMLLRRFRS RYWSPGRGGR 600
GAQEVASTLA SSPPSHFCPH PMSLSLSQPG PAPSPALTAP PPAYATLGPR PSPGGSAGAS 660
SSTCPLGGP 669 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell. GO:0030864; C:cortical actin cytoskeleton; IEA:Compara. GO:0009897; C:external side of plasma membrane; IEA:Compara. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0034706; C:sodium channel complex; IEA:Compara. GO:0015280; F:ligand-gated sodium channel activity; IEA:Compara. GO:0007588; P:excretion; TAS:ProtInc. GO:0034220; P:ion transmembrane transport; TAS:Reactome. GO:0050896; P:response to stimulus; IEA:UniProtKB-KW. GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW. GO:0006814; P:sodium ion transport; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |