CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026217
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 DNA-directed RNA polymerase I subunit RPA1 
Protein Synonyms/Alias
  
Gene Name
 Rpa1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
193AKAYGASKPFGKPAGacetylation[1, 2]
197GASKPFGKPAGTGLLacetylation[1, 2]
289NKVYYFSKGALKIANacetylation[1]
519PTQDCNKKVIDQQNGubiquitination[3]
607FTFRIRVKLETYNDEacetylation[2]
625KATVMDVKPVDFRDYubiquitination[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 644 AA 
Protein Sequence
MVGHLSEGAI EVMIQQENTS IKPILQVINI RPISTGNRSP RYRLLMSDGL NTLSSFMLAT 60
QLNTLVEGGQ LASNCVCQVH KFIVNTLKDG RMQPKPHGNP YGEQSVLRKL SQKVVVLMDL 120
EVMKSAEDVG LKIGNPVPYN EGYGQQQQQQ QQQQQQAVPS PASAATPPAS KPQPQNGSLG 180
MGSTAAKAYG ASKPFGKPAG TGLLQPSGGT QSKVVPIASL TPYQSKWTIC ARVTNKSQIR 240
TWSNSRGEGK LFSLELVDES GEIRATAFNE QVDKFFPLIE VNKVYYFSKG ALKIANKQFS 300
AVKNDYEMTF NNETSVLPCE DGHHLPTVQF DFTGIGDLES KAKDALVDII GICKSYEDSI 360
KITVKSNNRE VAKRNIYLMD MSGKVVTTTL WGEDADKFDG SRQPVMAIKG ARVSDFGGRS 420
LSVLSSSTVI VNPDIPEAYK LRGWFDSEGQ ALDGVSISDH RSGGAGGGNT NWKTLHEAKS 480
ENLGQGDKAD YFSTVAAVVF LRKENCMYQA CPTQDCNKKV IDQQNGLYRC EKCDREFPNF 540
KYRMILSANI ADFQENQWVT CFQESAEAIL GQNTMYLGEL KEKNEQAFEE VFQNANFRSF 600
TFRIRVKLET YNDESRIKAT VMDVKPVDFR DYGRRLIANI RKNM 644 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005662; C:DNA replication factor A complex; IEA:Compara.
 GO:0000800; C:lateral element; IDA:MGI.
 GO:0001673; C:male germ cell nucleus; IDA:MGI.
 GO:0016605; C:PML body; IEA:Compara.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0003697; F:single-stranded DNA binding; IEA:Compara.
 GO:0051276; P:chromosome organization; IMP:MGI.
 GO:0006260; P:DNA replication; IEA:InterPro.
 GO:0000724; P:double-strand break repair via homologous recombination; IMP:MGI.
 GO:0030097; P:hemopoiesis; IMP:MGI.
 GO:0048873; P:homeostasis of number of cells within a tissue; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0007126; P:meiosis; IDA:MGI.
 GO:0008284; P:positive regulation of cell proliferation; IMP:MGI. 
Interpro
 IPR012340; NA-bd_OB-fold.
 IPR004365; NA-bd_OB_tRNA-helicase.
 IPR013955; Rep_factor-A_C.
 IPR007199; Rep_factor-A_N.
 IPR004591; Rep_factor_Rpa1. 
Pfam
 PF04057; Rep-A_N
 PF08646; Rep_fac-A_C
 PF01336; tRNA_anti 
SMART
  
PROSITE
  
PRINTS