| Tag | Content |
|---|
| CPLM ID | CPLM-013478 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ribosome biogenesis protein BOP1 |
Protein Synonyms/Alias | Block of proliferation 1 protein |
Gene Name | Bop1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 18 | SPGSLPGKRRLEPDQ | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome (By similarity). |
Sequence Annotation | REPEAT 396 435 WD 1.
REPEAT 437 477 WD 2.
REPEAT 517 559 WD 3.
REPEAT 562 600 WD 4.
REPEAT 603 642 WD 5.
REPEAT 646 685 WD 6.
REPEAT 701 731 WD 7.
REGION 250 412 Sufficient for nucleolar localization (By
MOD_RES 111 111 Phosphoserine (By similarity).
MOD_RES 112 112 Phosphoserine (By similarity). |
Keyword | Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 731 AA |
Protein Sequence | MAGACGKHHM SPGSLPGKRR LEPDQEPQIQ EPLLLSDPDS SLSDSEESVF SGLEDSGSDT 60
SDEDTEEVAR AGCDKDNRTE KTSEEQEQAV PPCPRAEEAG ALTRDEYEED SSDEEDIRNT 120
VGNVPLAWYD DFPHVGYDLD GKRIYKPLRT RDELDQFLDK MDDPDFWRTV QDKMTGSDLR 180
LTDEQVALVH RLQRGQFGDS GFDPYEPAVD FFSGDIMIHP VTNRPADKRS FIPSLVEKEK 240
VSRLVHAIKM GWIKPRRPPD STPSFYDLWA QEDPNAVLGR HKMHVPAPKL ALPGHAESYN 300
PPPEYLPTEE ERLAWMQQEP IERKLNFLPQ KFPSLRTVPA YGRFIQERFE RCLDLYLCPR 360
QRKMRVNVDP EDLIPKLPRP RDLQPFPVCQ ALVYRGHSDL VRCLSVSPGG QWLASGSDDG 420
TLRLWEVATA RCMKTVRVGG VIRSIAWNPN PTICLVAAAM DDAVVLLNPA LGDRLLVGST 480
DQLLETFTPP EEPTLQPAHW LEVSEEERQR GLRLRICHSK PVTQVTWHGR GDYLAVVLSS 540
QGHTQVLIHQ LSRRRSQSPF RRSHGQVQCV AFHPTRPFLL VASQRSIRIY HLLRQELTKK 600
LMPNCKWVSS MAVHPAGDNI ICGSYDSKLV WFDLDLSTKP YKVLRHHKKA LRAVAFHPRY 660
PLFASGSDDG SVIVCHGMVY NDLLQNPLLV PVKVLKGHSL TRDLGVLDVA FHPTQPWVFS 720
SGADGTIRLF S 731 |
Gene Ontology | GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell. GO:0070545; C:PeBoW complex; ISS:UniProtKB. GO:0043021; F:ribonucleoprotein complex binding; IEA:Compara. GO:0008283; P:cell proliferation; IEA:Compara. GO:0000448; P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:Compara. GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB. GO:0051726; P:regulation of cell cycle; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |