CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015563
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cadherin-related family member 3 
Protein Synonyms/Alias
 Cadherin-like protein 28 
Gene Name
 CDHR3 
Gene Synonyms/Alias
 CDH28 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
802KTGARKWKDPLTQMPacetylation[1]
812LTQMPKWKESSHQGAacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. 
Sequence Annotation
 DOMAIN 23 132 Cadherin 1.
 DOMAIN 136 236 Cadherin 2.
 DOMAIN 237 344 Cadherin 3.
 DOMAIN 346 466 Cadherin 4.
 DOMAIN 462 566 Cadherin 5.
 DOMAIN 567 695 Cadherin 6.
 CARBOHYD 186 186 N-linked (GlcNAc...) (Potential).
 CARBOHYD 257 257 N-linked (GlcNAc...) (Potential).
 CARBOHYD 624 624 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Calcium; Cell adhesion; Cell membrane; Complete proteome; Glycoprotein; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 885 AA 
Protein Sequence
MQEAIILLAL LGAMSGGEAL HLILLPATGN VAENSPPGTS VHKFSVKLSA SLSPVIPGFP 60
QIVNSNPLTE AFRVNWLSGT YFEVVTTGME QLDFETGPNI FDLQIYVKDE VGVTDLQVLT 120
VQVTDVNEPP QFQGNLAEGL HLYIVERANP GFIYQVEAFD PEDTSRNIPL SYFLISPPKS 180
FRMSANGTLF STTELDFEAG HRSFHLIVEV RDSGGLKAST ELQVNIVNLN DEVPRFTSPT 240
RVYTVLEELS PGTIVANITA EDPDDEGFPS HLLYSITTVS KYFMINQLTG TIQVAQRIDR 300
DAGELRQNPT ISLEVLVKDR PYGGQENRIQ ITFIVEDVND NPATCQKFTF SIMVPERTAK 360
GTLLLDLNKF CFDDDSEAPN NRFNFTMPSG VGSGSRFLQD PAGSGKIVLI GDLDYENPSN 420
LAAGNKYTVI IQVQDVAPPY YKNNVYVYIL TSPENEFPLI FDRPSYVFDV SERRPARTRV 480
GQVRATDKDL PQSSLLYSIS TGGASLQYPN VFWINPKTGE LQLVTKVDCE TTPIYILRIQ 540
ATNNEDTSSV TVTVNILEEN DEKPICTPNS YFLALPVDLK VGTNIQNFKL TCTDLDSSPR 600
SFRYSIGPGN VNNHFTFSPN AGSNVTRLLL TSRFDYAGGF DKIWDYKLLV YVTDDNLMSD 660
RKKAEALVET GTVTLSIKVI PHPTTIITTT PRPRVTYQVL RKNVYSPSAW YVPFVITLGS 720
ILLLGLLVYL VVLLAKAIHR HCPCKTGKNK EPLTKKGETK TAERDVVVET IQMNTIFDGE 780
AIDPVTGETY EFNSKTGARK WKDPLTQMPK WKESSHQGAA PRRVTAGEGM GSLRSANWEE 840
DELSGKAWAE DAGLGSRNEG GKLGNPKNRN PAFMNRAYPK PHPGK 885 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0007156; P:homophilic cell adhesion; IEA:InterPro. 
Interpro
 IPR002126; Cadherin.
 IPR015919; Cadherin-like. 
Pfam
 PF00028; Cadherin 
SMART
 SM00112; CA 
PROSITE
 PS00232; CADHERIN_1
 PS50268; CADHERIN_2 
PRINTS
 PR00205; CADHERIN.