CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039602
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Activating transcription factor 7-interacting protein 1 
Protein Synonyms/Alias
  
Gene Name
 ATF7IP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
576DMDNVQSKRRRYMEEubiquitination[1, 2]
596FQVKITAKGDINQKLubiquitination[2]
602AKGDINQKLQKVIQWubiquitination[1, 2, 3]
605DINQKLQKVIQWLLEubiquitination[1, 2, 3, 4, 5, 6]
644IECNKRHKTVLTELQubiquitination[2]
653VLTELQAKIARLTKRubiquitination[2, 4, 6, 7]
946RIENQTNKTIDASVSacetylation[3]
1171ASTSLPQKPHLKLARubiquitination[4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [7] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1278 AA 
Protein Sequence
MHQDQRFRMD SLEEPQKKVF KARKTMRVSD RQQLEAVYKV KEELLKTDVK LLNGNHENGD 60
LDPTSPLENM DYIKDKEEVN GIEEICFDPE GSKAEWKETP CILSVNVKNK QDDDLNCEPL 120
SPHNITPEPV SKLPAEPVSG DPAPGDLDAG DPASGVLASG DSTSGDPTSS EPSSSDAASG 180
DATSGDAPSG DVSPGDATSG DATADDLSSG DPTSSDPIPG EPVPVEPISG DCAADDIASS 240
EITSVDLASG APASTDPASD DLASGDLSSS ELASDDLATG ELASDELTSE STFDRTFEPK 300
SVPVCEPVPE IDNIEPSSNK DDDFLEKNGA DEKLEQIQSK DSLDEKNKAD NNIDANEETL 360
ETDDTTICSD RPPENEKKVE EDIITELALG EDAISSSMEI DQGEKNEDET SADLVETINE 420
NVIEDNKSEN ILENTDSMET DEIIPILEKL APSEDELTCF SKTSLLPIDE TNPDLEEKME 480
SSFGSPSKQE SSESLPKEAF LVLSDEEDIS GEKDESEVIS QNETCSPAEV ESNEKDNKPE 540
EEEQVIHEDD ERPSEKNEFS RRKRSKSEDM DNVQSKRRRY MEEEYEAEFQ VKITAKGDIN 600
QKLQKVIQWL LEEKLCALQC AVFDKTLAEL KTRVEKIECN KRHKTVLTEL QAKIARLTKR 660
FEAAKEDLKK RHEHPPNPPV SPGKTVNDVN SNNNMSYRNA GTVRQMLESK RNVSESAPPS 720
FQTPVNTVSS TNLVTPPAVV SSQPKLQTPV TSGSLTATSV LPAPNTATVV ATTQVPSGNP 780
QPTISLQPLP VILHVPVAVS SQPQLLQSHP GTLVTNQPSG NVEFISVQSP PTVSGLTKNP 840
VSLPSLPNPT KPNNVPSVPS PSIQRNPTAS AAPLGTTLAV QAVPTAHSIV QATRTSLPTV 900
GPSGLYSPST NRGPIQMKIP ISAFSTSSAA EQNSNTTPRI ENQTNKTIDA SVSKKAADST 960
SQCGKATGSD SSGVIDLTMD DEESGASQDP KKLNHTPVST MSSSQPVSRP LQPIQPAPPL 1020
QPSGVPTSGP SQTTIHLLPT APTTVNVTHR PVTQVTTRLP VPRAPANHQV VYTTLPAPPA 1080
QAPLRGTVMQ APAVRQVNPQ NSVTVRVPQT TTYVVNNGLT LGSTGPQLTV HHRPPQVHTE 1140
PPRPVHPAPL PEAPQPQRLP PEAASTSLPQ KPHLKLARVQ SQNGIVLSWS VLEVDRSCAT 1200
VDSYHLYAYH EEPSATVPSQ WKKIGEVKAL PLPMACTLTQ FVSGSKYYFA VRAKDIYGRF 1260
GPFCDPQSTD VISSTQSS 1278 
Gene Ontology
  
Interpro
 IPR026085; ATF7-int.
 IPR003961; Fibronectin_type3.
 IPR013783; Ig-like_fold. 
Pfam
  
SMART
  
PROSITE
 PS50853; FN3 
PRINTS