UniProt Accession

 B1ANG9_HUMAN; B1ANG9 

Genbank Protein ID

 AL359510 

Genbank Nucleotide ID

  

Protein Name

 Guanylate kinase 

Protein Synonyms/Alias

  

Gene Name

 GUK1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
72	RPGEENGKDYYFVTR	ubiquitination	[1]
132	LQGVRNIKATDLRPI	ubiquitination	[2]
168	ETEESLVKRLAAAQA	ubiquitination	[2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 218 AA 

Protein Sequence

Gene Ontology

 GO:0004385; F:guanylate kinase activity; IEA:InterPro.
 GO:0006163; P:purine nucleotide metabolic process; IEA:InterPro. 

Interpro

 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR020590; Guanylate_kinase_CS.
 IPR017665; Guanylate_kinase_sub.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00625; Guanylate_kin 

SMART

 SM00072; GuKc 

PROSITE

 PS00856; GUANYLATE_KINASE_1
 PS50052; GUANYLATE_KINASE_2 

PRINTS