UniProt Accession

 TWSG1_HUMAN; Q9GZX9; B2RE08; D3DUH9; Q8NBI7; Q96K46 

Genbank Protein ID

 AF196834; AJ297391; AF294628; AK027629; AK075550; AK315751; AP001033; CH471113; CH471113; BC020490 

Genbank Nucleotide ID

 AAG43468.1; CAC05581.1; AAG10076.1; BAB55246.1; BAC11693.1; BAG38105.1; EAX01606.1; EAX01607.1; AAH20490.1 

Protein Name

 Twisted gastrulation protein homolog 1 

Protein Synonyms/Alias

  

Gene Name

 TWSG1 

Gene Synonyms/Alias

 TSG; PSEC0250 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
192	CESMGASKYRWFHNA	ubiquitination	[1]
214	ECIDYGSKTVKCMNC	ubiquitination	[1]
217	DYGSKTVKCMNCMF*	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity). 

Sequence Annotation

 CARBOHYD 52 52 N-linked (GlcNAc...) (Potential).
 CARBOHYD 81 81 N-linked (GlcNAc...) (Potential).  

Keyword

 Alternative splicing; Complete proteome; Developmental protein; Glycoprotein; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 223 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0030509; P:BMP signaling pathway; IEA:Compara.
 GO:0043010; P:camera-type eye development; IEA:Compara.
 GO:0030154; P:cell differentiation; IEA:Compara.
 GO:0030900; P:forebrain development; IEA:Compara.
 GO:0030097; P:hemopoiesis; IEA:Compara.
 GO:0001707; P:mesoderm formation; IEA:Compara.
 GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Compara.
 GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Compara.
 GO:0001503; P:ossification; IEA:Compara.
 GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Compara.
 GO:0007435; P:salivary gland morphogenesis; IEA:Compara. 

Interpro

 IPR006761; Tsg. 

Pfam

 PF04668; Tsg 

SMART

  

PROSITE

  

PRINTS