| Tag | Content |
|---|
| CPLM ID | CPLM-019936 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phosphatidylserine synthase 1 |
Protein Synonyms/Alias | PSS-1; PtdSer synthase 1; Serine-exchange enzyme I |
Gene Name | Ptdss1 |
Gene Synonyms/Alias | Pssa |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 12 | VGSRTLSKDDVNYRM | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine. |
Sequence Annotation | MOD_RES 417 417 Phosphoserine (By similarity).
MOD_RES 425 425 Phosphoserine (By similarity).
MOD_RES 442 442 Phosphoserine (By similarity).
MOD_RES 454 454 Phosphoserine (By similarity). |
Keyword | Complete proteome; Endoplasmic reticulum; Lipid biosynthesis; Lipid metabolism; Membrane; Phospholipid biosynthesis; Phospholipid metabolism; Phosphoprotein; Reference proteome; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 473 AA |
Protein Sequence | MASCVGSRTL SKDDVNYRMH FRMINEQQVE DITIDFFYRP HTITLLSFTI ISLMYFAFTR 60
DDSVPEDNIW RGILSVIFFF LIISVLAFPN GPFTRPHPAL WRMVFGLSVL YFLFLVFLLF 120
LNFEQVKSLM YWLDPNLRYA TREADIMEYA VNCHVITWER IVSHFDIFAF GHFWGWAMKA 180
LLIRSYGLCW TISITWELTE LFFMHLLPNF AECWWDQVIL DILLCNGGGI WLGMVVCRFL 240
EMRTYHWASF KDIHTTTGKI KRAVLQFTPA SWTYVRWFDP KSSFQRVAGI YLFMIIWQLT 300
ELNTFFLKHI FVFQASHPLS WGRILFIGCI TAPTVRQYYA YLTDTQCKRV GTQCWVFGVI 360
GFLEAIVCIK FGQDLFSKTQ ILYVMLWLLC VAFTTFLCLY GMVWYAEHYG HREKTYSECE 420
DGTYSPEISW HHGKGSKGSE DSPPKHSSNH ESHSSRRRNR HSKSKVTNGV GKK 473 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016740; F:transferase activity; IEA:UniProtKB-KW. GO:0006659; P:phosphatidylserine biosynthetic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |