| Tag | Content |
|---|
| CPLM ID | CPLM-017189 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ankyrin repeat and SOCS box protein 2 |
Protein Synonyms/Alias | ASB-2 |
Gene Name | Asb2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 99 | KYSSNLFKTSQMAAM | ubiquitination | [1] | | 114 | DPVLKAIKEGDEEAL | ubiquitination | [1] | | 573 | VQLCSRLKEHIDSFE | ubiquitination | [1] | | 586 | FEDWAVIKEKAEPPR | ubiquitination | [1] | | 613 | AIGKYRIKLLDTLPL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). |
Sequence Annotation | REPEAT 26 45 UIM.
REPEAT 104 133 ANK 1.
REPEAT 137 167 ANK 2.
REPEAT 171 200 ANK 3.
REPEAT 204 233 ANK 4.
REPEAT 237 266 ANK 5.
REPEAT 270 299 ANK 6.
REPEAT 303 332 ANK 7.
REPEAT 336 365 ANK 8.
REPEAT 368 397 ANK 9.
REPEAT 410 439 ANK 10.
REPEAT 440 469 ANK 11.
REPEAT 476 504 ANK 12.
DOMAIN 580 634 SOCS box. |
Keyword | Alternative splicing; ANK repeat; Complete proteome; Reference proteome; Repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 634 AA |
Protein Sequence | MATEISTRGR QRAIGHEEYS LYSSLSEEEL LQMAIEQSLA DKTRGPTPAE ASASSQTNHQ 60
PGHFHPWTRS PSSPENPPAR APLGLFQGVM QKYSSNLFKT SQMAAMDPVL KAIKEGDEEA 120
LKIMIQDGKN LAEPNKEGWL PLHEAAYYGQ LGCLKVLQQA YPGTIDQRTL QEETALYLAT 180
CREHLDCLLS LLQAGAEPDI SNKSRETPLY KACERKNAEA VRILVRYNAD ANHRCNRGWT 240
ALHESVSRND LEVMEILVSG GAKVEAKNVY SITPLFVAAQ SGQLEALRFL AKHGADINTQ 300
ASDSASALYE ASKNEHEDVV EFLLSQGADA NKANKDGLLP LHVASKKGNY RIVQMLLPVT 360
SRTRVRRSGI SPLHLAAERN HDAVLEALLA ARFDVNAPLA PERARLYEDR RSSALYFAVV 420
NNNVYATELL LLAGADPNRD VISPLLVAIR HGCLRTMQLL LDHGANIDAY IATHPTAFPA 480
TIMFAMKCLS LLKFLMDLGC DGEPCFSCLY GNGPHPPAPR PGRFHDAPVD DKAPSVVQFC 540
EFLSAPEVSR WAGPIIDVLL DYVGNVQLCS RLKEHIDSFE DWAVIKEKAE PPRPLAHLCR 600
LRVRKAIGKY RIKLLDTLPL PGRLIRYLKY ENTQ 634 |
Gene Ontology | GO:0031466; C:Cul5-RING ubiquitin ligase complex; IDA:MGI. GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0045445; P:myoblast differentiation; IMP:MGI. GO:0000209; P:protein polyubiquitination; IDA:MGI. GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:MGI. GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |