CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042320
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 SLIT-ROBO Rho GTPase-activating protein 2 
Protein Synonyms/Alias
  
Gene Name
 SRGAP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
2******XKDQNVLSPubiquitination[1]
57GRLFKKSKEVGQQLQubiquitination[1]
94DSISAQSKLKEAEKQubiquitination[1, 2]
220ELNLEQSKHEGLDAIubiquitination[2, 3]
240NLDATSDKQRLMEMYubiquitination[2, 3]
295QSRLSTLKIENEEVKubiquitination[1]
347VSETFMSKPSIAKRRubiquitination[3]
384LITKLQAKHDLLQKTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 985 AA 
Protein Sequence
XKDQNVLSPV NCWNLLLNQV KRESRDHTTL SDIYLNNIIP RFVQVSEDSG RLFKKSKEVG 60
QQLQDDLMKV LNELYSVMKT YHMYNADSIS AQSKLKEAEK QEEKQIGKSV KQEDRQTPRS 120
PDSTANVRIE EKHVRRSSVK KIEKMKEKRQ AKYTENKLKA IKARNEYLLA LEATNASVFK 180
YYIHDLSDLI DQCCDLGYHA SLNRALRTFL SAELNLEQSK HEGLDAIENA VENLDATSDK 240
QRLMEMYNNV FCPPMKFEFQ PHMGDMASQL CAQQPVQSEL VQRCQQLQSR LSTLKIENEE 300
VKKTMEATLQ TIQDIVTVED FDVSDCFQYS NSMESVKSTV SETFMSKPSI AKRRANQQET 360
EQFYFTKMKE YLEGRNLITK LQAKHDLLQK TLGESQRTDC SLARRSSTVR KQDSSQAIPL 420
VVESCIRFIS RHGLQHEGIF RVSGSQVEVN DIKNAFERGE DPLAGDQNDH DMDSIAGVLK 480
LYFRGLEHPL FPKDIFHDLM ACVTMDNLQE RALHIRKVLL VLPKTTLIIM RYLFAFLNHL 540
SQFSEENMMD PYNLAICFGP SLMSVPEGHD QVSCQAHVNE LIKTIIIQHE NIFPSPRELE 600
GPVYSRGGSM EDYCDSPHGE TTSVEDSTQD VTAEHHTSDD ECEPIEAIAK FDYVGRTARE 660
LSFKKGASLL LYQRASDDWW EGRHNGIDGL IPHQYIVVQD TEDGVVERSS PKSEIEVISE 720
PPEEKVTARA GASCPSGGHV ADIYLANINK QRKRPESGSI RKTFRSDSHG LSSSLTDSSS 780
PGVGASCRPS SQPIMSQSLP KEGPDKCSIS GHGSLNSISR HSSLKNRLDS PQIRKTATAG 840
RSKSFNNHRP MDPEVIAQDI EATMNSALNE LRELERQSSV KHTPDVVLDT LEPLKTSPVV 900
APTSEPSSPL HTQLLKDPEP AFQRSASTAG DIACAFRPVK SVKMAAPVKP PATRPKPTVF 960
PKTNATSPGV NSSTSPQSTD KSCTV 985 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom.
 IPR001452; SH3_domain. 
Pfam
 PF00620; RhoGAP
 PF00018; SH3_1 
SMART
 SM00324; RhoGAP
 SM00326; SH3 
PROSITE
 PS50238; RHOGAP
 PS50002; SH3 
PRINTS