CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038279
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Malic enzyme 
Protein Synonyms/Alias
  
Gene Name
 Me3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
95IPKTEAIKKIWMVDSacetylation[1]
282VSLRIAVKVLDYAYKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 METAL 11 11 Divalent metal cation (By similarity).
 METAL 12 12 Divalent metal cation (By similarity).
 METAL 35 35 Divalent metal cation (By similarity).  
Keyword
 Complete proteome; Metal-binding; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 335 AA 
Protein Sequence
MFGINCLIQF EDFANANAFR LLNKYRNKYC MFNDDIQGTA SVAVAGILAA LRITKNRLSN 60
HVFVFQGAGE AAMGIAHLLV MALEKEGIPK TEAIKKIWMV DSKGLIVKGR SHLNHEKEMF 120
AQDHPEVNSL EEVVRLVKPT AIIGVAAIAG AFTEQILRDM ASFHERPIVF ALSNPTSKAE 180
CTAEKCYRVT EGRGIFASGS PFKSVTLEDG RTFTPGQGNN AYVFPGVALG VIAGGIRHIP 240
DEIFLLTAEQ IAQEVSEQHL SQGRLYPPLS TIRDVSLRIA VKVLDYAYKH NLASYYPEPK 300
DKEAFVKSLI YTPDYDSFSL DTYSWPKEAM SVQKV 335 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0016619; F:malate dehydrogenase (oxaloacetate-decarboxylating) activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006108; P:malate metabolic process; IEA:InterPro. 
Interpro
 IPR015884; Malic_enzyme_CS.
 IPR012301; Malic_N.
 IPR012302; Malic_NAD-bd.
 IPR001891; Malic_OxRdtase.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00390; malic
 PF03949; Malic_M 
SMART
 SM00919; Malic_M 
PROSITE
 PS00331; MALIC_ENZYMES 
PRINTS
 PR00072; MALOXRDTASE.