CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039155
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sodium channel protein type 3 subunit alpha 
Protein Synonyms/Alias
  
Gene Name
 Scn3a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
454QMLEQLKKQQEEAQAubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Sodium; Sodium channel; Sodium transport; Transmembrane; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1950 AA 
Protein Sequence
MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDIDDENKPK PNSDLEAGKN 60
LPFIYGDIPP EMVSEPLEDL DPYYVSKKTF VVLNKGKAIF RFSATSALYI LTPLNPVRKI 120
AIKILKPSLL HMLIMCTILT NCVFMTLSNP PDWTKNVEYT FTGIYTFESL IKILARGFCL 180
EDFTFLRDPW NWLDFSVIVM AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL 240
IQSVKKLSDV MILTVFCLSV FALIGLQLFM GNLRNKCLQW PPSDSAFETN TTSYFNGTMD 300
SNGTFVNVTM STFNWKDYIA DDSHFYVLDG QKDPLLCGNG SDAGQCPEGY ICVKAGRNPN 360
YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY MIFFVLVIFL GSFYLVNLIL 420
AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE QLKKQQEEAQ AVAAASAASR DFSGIGGLGE 480
LLESSSEASK LSSKSAKEWR NRRKKRRQRE HLEGNHRADG DRFPKSESED SVKRRSFLLS 540
LDGNPLTGDK KLCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST 600
FEDSESRRDS LFVPHRPGER RNSNGTTTET EVRKRRLSSY QISMEMLEDS SGRQRAMSIA 660
SILTNTMEEL EESRQKCPPC WYRFANVFLI WDCCDAWLKV KHLVNLIVMD PFVDLAITIC 720
IVLNTLFMAM EHYPMTQQFS SVLTVGNLVF TGIFTAEMVL KIIAMDPYYY FQEGWNIFDG 780
IIVSLSLMEL GLANVEGLSV LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL 840
AIIVFIFAVV GMQLFGKSYK ECVCKINVDC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW 900
DCMEVAGQTM CLIVFMLVMV IGNLVVLNLF LALLLSSFSS DNLAATDDDN EMNNLQIAVG 960
RMQKGIDFVK NKIRECFRKA FFRKPKVIEI QEGNKIDSCM SNNTGIEISK ELNYLKDGNG 1020
TTSGVGTGSS VEKYVIDEND YMSFINNPSL TVTVPIAVGE SDFENLNTEE FSSESELEES 1080
KEKLNATSSS EGSTVDVAPP REGEQAEIEP EEDLKPEACF TEGCIKKFPF CQVSTEEGKG 1140
KIWWNLRKTC YSIVEHNWFE TFIVFMILLS SGALAFEDIY IEQRKTIKTM LEYADKVFTY 1200
IFILEMLLKW VAYGFQTYFT NAWCWLDFLI VDVSLVSLVA NALGYSELGA IKSLRTLRAL 1260
RPLRALSRFE GMRVVVNALV GAIPSIMNVL LVCLIFWLIF SIMGVNLFAG KFYHCVNTTT 1320
GNMFEIKEVN NFSDCQALGK QARWKNVKVN FDNVGAGYLA LLQVATFKGW MDIMYAAVDS 1380
RDVKLQPIYE ENLYMYLYFV IFIIFGSFFT LNLFIGVIID NFNQQKKKMS QDIFMTEEQK 1440
KYYNAMKKLG SKKPQKPIPR PANKFQGMVF DFVTRQVFDI SIMILICLNM VTMMVETDDQ 1500
SKYMTLVLSR INLVFIVLFT GEFLLKLISL RYYYFTIGWN IFDFVVVILS IVGMFLAELI 1560
EKYFVSPTLF RVIRLARIGR ILRLIKGAKG IRTLLFALMM SLPALFNIGL LLFLVMFIYA 1620
IFGMSNFAYV KKEAGIDDMF NFETFGNSMI CLFQITTSAG WDGLLAPILN SAPPDCDPDA 1680
IHPGSSVKGD CGNPSVGIFF FVSYIIISFL VVVNMYIAVI LENFSVATEE SAEPLSEDDF 1740
EMFYEVWEKF DPDATQFIEF CKLSDFAAAL DPPLLIAKPN KVQLIAMDLP MVSGDRIHCL 1800
DILFAFTKRV LGESGEMDAL RIQMEERFMA SNPSKVSYEP ITTTLKRKQE EVSAAIIQRN 1860
YRCYLLKQRL KNISSKYDKE TIKGRIDLPI KGDMVIDKLN GNSTPEKTDG SSSTTSPPSY 1920
DSVTKPDKEK FEKDKPEKEI KGKEVRENQK 1950 
Gene Ontology
 GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
 GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
 GO:0035725; P:sodium ion transmembrane transport; IEA:GOC. 
Interpro
 IPR024583; DUF3451.
 IPR005821; Ion_trans_dom.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027359; K_channel_four-helix_dom.
 IPR001696; Na_channel_asu.
 IPR010526; Na_trans_assoc. 
Pfam
 PF11933; DUF3451
 PF00520; Ion_trans
 PF06512; Na_trans_assoc 
SMART
 SM00015; IQ 
PROSITE
  
PRINTS
 PR00170; NACHANNEL.