UniProt Accession

 RL14_MOUSE; Q9CR57; Q9D8Q1 

Genbank Protein ID

 AK007807; AK012277; AK013912 

Genbank Nucleotide ID

 BAB25272.1; BAB28136.1; BAB29051.1 

Protein Name

 60S ribosomal protein L14 

Protein Synonyms/Alias

  

Gene Name

 Rpl14 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
53	RRQAMPFKCMQLTDF	acetylation	[1]
63	QLTDFILKFPHSARQ	ubiquitination	[2]
79	YVRKAWEKADINTKW	acetylation	[3, 4, 5]
79	YVRKAWEKADINTKW	succinylation	[4]
79	YVRKAWEKADINTKW	ubiquitination	[2]
85	EKADINTKWAATRWA	acetylation	[1, 3, 4, 5, 6]
85	EKADINTKWAATRWA	succinylation	[4]
85	EKADINTKWAATRWA	ubiquitination	[2]
103	DARERKAKMTDFDRF	ubiquitination	[2]
147	PKKAAVAKAAIAAAA	ubiquitination	[2]
160	AAAAAAAKAKVPAKK	acetylation	[4]
160	AAAAAAAKAKVPAKK	succinylation	[4]
160	AAAAAAAKAKVPAKK	ubiquitination	[2]
189	AQKAAGQKAAPPAKG	acetylation	[4]
189	AQKAAGQKAAPPAKG	succinylation	[4]
206	GQKTPAQKAPAPKAA	acetylation	[4]
206	GQKTPAQKAPAPKAA	succinylation	[4]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

 REPEAT 173 177 1-1; approximate.
 REPEAT 178 182 1-2.
 REPEAT 183 187 1-3.
 REPEAT 188 192 1-4.
 REPEAT 195 197 2-1.
 REPEAT 198 200 2-2.
 REGION 173 192 4 X 5 AA tandem repeats of Q-K-A-[APS]-X.
 REGION 195 200 2 X 3 AA tandem repeats of K-G-Q.
 MOD_RES 79 79 N6-acetyllysine (By similarity).
 MOD_RES 85 85 N6-acetyllysine (By similarity).
 MOD_RES 139 139 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; Ribosomal protein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 217 AA 

Protein Sequence

Gene Ontology

 GO:0022625; C:cytosolic large ribosomal subunit; IEA:Compara.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0042273; P:ribosomal large subunit biogenesis; IEA:Compara.
 GO:0006364; P:rRNA processing; IEA:Compara.
 GO:0006412; P:translation; IEA:InterPro. 

Interpro

 IPR014722; Rib_L2_dom2.
 IPR002784; Ribosomal_L14. 

Pfam

 PF01929; Ribosomal_L14e 

SMART

  

PROSITE

  

PRINTS